IRCT20190724044322N2尚未招募3 期
The effect of myo-inositol supplementation and placebo on the expression level of SIRT-1 pathway genes (SIRT-1, eNOS, NF-kB, LDLR, LOX-1, LXRa, ABCA1 and PCSK9) involved in atherosclerosis in peripheral blood mononuclear cells of patients with non-alcoholic fatty liver disease
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 44
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 55 years（—）
- 性别
- All
入选标准
- •Age 18-55 years
- •Body mass index in the range of 30-40 Kg / m2
- •Willingness to cooperate
- •Hepatic steatosis based on Grade 1 and 2 NAFLD disease
排除标准
- •Athlete, pregnancy, lactation and menopause in women
- •Infertility treatment, taking oral contraceptive pills
- •Smoking and alcohol use
- •Adherence to a special diet 3 months before the study
- •Use of chemical or herbal medicines for weight loss and use of hepatotoxic drugs such as phenytoin, amoxifine , lithium and insulin sensitizer medications, antibiotics or any kind of supplements that may affect liver enzymes
- •History of weight loss surgery over the last year or rigid weight loss diets three months before the trial
- •Use of NSAIDs or any any multivitamin or supplements for 3 months before or during the study
- •those with cardiovascular disease, hepatic, renal, intestinal, thyroid and parathyroid dysfunction, billiary disease, known autoimmune diseases, PCOs, cancers and conditions
- •use of any antihypertensive drugs and lipid-lowering drugs (statins) and medications related to cardiovascular patients
- •Candidate or history of Liver transplant
- •Intention for pregnancy
研究者
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