External Surface Cooling In huMan endOtoxemia
Completed
- Conditions
- 10004018endotoxemiaSepsis
- Registration Number
- NL-OMON45163
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy male volunteer
2. Age >= 18 years <35 years
3. BMI 20-25
Exclusion Criteria
1. No informed consent
2. Any abnormal test result during the screening prior to inclusion of the study (medical history, physical examination, ECG, blood examination).
3. History of drug abuse
4. Any present medication use on prescription
5. Participation in any other medical drug study < 3 months
6. Participation in previous volunteer studies using LPS
7. History of an allergic reaction to opiates
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>A significant decrease in plasma Il-6 levels</p><br>
- Secondary Outcome Measures
Name Time Method <p>Other markers of<br /><br>1. host immune response<br /><br>2. coagulation<br /><br>3. tissue perfusion and oxygenation<br /><br>4. neurovascular coupling</p><br>