Clinical evaluation of high resolution retinal ganglion cell imaging

Not Applicable

• Conditions: glaucoma, retinal diseases, optic nerve associated diseases

• Registration Number: JPRN-UMIN000045092
• Lead Sponsor: Kyoto University Graduate School of Medicine,Department of Ophthalmology & Visual Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-08-08
• Last Update Posted: 17 October 2023
• Study Completion: 2023-10-31

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

Glaucoma group (glaucomatous eyes) 1) History of retinal disease (macular edema, retinal detachment, diabetic retinopathy, pathological myopia, etc.) or optic neuropathy other than glaucoma 2) Severe glaucoma (MD below -12 dB, etc.) 3) History of adverse reaction (hypersensitivity, increased intraocular pressure, etc.) to mydriatic agent 4) Narrow angle is observed in a slit-lamp examination, and mydriasis is considered to have a high risk of inducing an acute glaucoma attack. 5) Inability to perform appropriate fundus observation using AO-OCT due to lens opacity caused by cataract. 6) Lack of corrected visual acuity to perform visual field testing appropriately. 7) History of corneal refractive surgery or severe ocular trauma. 8) Corneal or conjunctival abnormality that prevents appropriate measurement of intraocular pressure using a tonometer 9) Other cases that the principal investigator or the physician in charge deems inappropriate for the safe conduct of this study Control group (healthy eyes) In addition to 3) to 9) of "Glaucoma eyes," the following will be included. 1) Suspected glaucoma, anterior segment glaucoma, retinal disease (macular edema, retinal detachment, diabetic retinopathy, pathological myopia, etc.), or a history of optic neuropathy other than glaucoma

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Each of the following items will be evaluated, as well as the correlation between each item. 1) Items to examine the difference between healthy and pathological eyes Various parameters of cells in the retina, including retinal ganglion cells (number of cells at each position in the retina, cell density, cell arrangement, etc.) 2) Items to be examined for differences between the test device and other ophthalmic devices (OCT, etc.) Findings based on images and measurement data 3) Items to examine the differences in physical findings Translated with www.DeepL.com/Translator (free version)