Feasibility of fibered confocal fluorescence microscopy (FCFM) in patients with pulmonary diseases.
- Conditions
- pulmonary diseases10006436
- Registration Number
- NL-OMON32614
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Adult patients (18-75 yr) with the following pulmonary diseases will be studied:
1. three patients with a peripheral lung tumor who undergo bronchoscopy as part
of the routine assessment
2. three patients with a previous diagnosis or clinical suspicion of sarcoidosis.
3. three patients with COPD (GOLD II-IV) (smokers or ex-smokers,
postbronchodilator (after inhalation of 400 mcg salbutamol) FEV1/FVC <70%,
reversibility <9%)
4. three patients with asthma (nonsmokers, reversibility of FEV1 > 12% after
inhalation of 400 mcg salbutamol)
Exclusion Criteria
Patients who are > 80 years of age or who have previously undergone radiotherapy will be excluded.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The microscopic autofluorescence structure of normal and pathologic bronchial<br /><br>mucosae will be analysed. Pathology specimens will analyzed by a pathologists<br /><br>with expertise in pulmonary disorders. Characteristics of images will be<br /><br>defined, and related to the pathological findings.</p><br>
- Secondary Outcome Measures
Name Time Method <p>NA</p><br>