NCT00710099已完成不适用
Effect of Oral Sildenafil With Digital Therapeutic Iontophoresis of Sodium Nitroprussiate on Cutaneous Blood Flow in Healthy Volunteers
University Hospital, Grenoble1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2008年7月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- variation of conductance of nitroprussiate iontophoresis associated with oral sildenafil
研究概览
简要总结
Iontophoresis is a employed to facilitate drug absorption without systemic effect. This study investigates cutaneous microcirculation when we associate sildenafil per os with SNP via iontophoresis.
详细描述
The main outcome is the proof of concept of effect of systemic absorption sildenafil on cutaneous microcirculation associated with SNP iontophoresis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age over 18
- •No significant medical history
排除标准
- •Age under 18
- •Period of exclusion for an other study
- •Pregnancy
- •Breast feeding
- •Severe disease
- •Cigarette smoking
研究组 & 干预措施
1
Experimental
干预措施: sildenafil (Drug)
2
Active Comparator
SNP iontophoresis
干预措施: nitroprussiate iontophoresis (Drug)
结局指标
主要结局
variation of conductance of nitroprussiate iontophoresis associated with oral sildenafil
时间窗: one hour
次要结局
- To assess the effect of oral sildenafil (50 mg and 100 mg) on skin microvascular reactivity to local cooling, on the forearm and the finger(one hour)
研究者
研究点 (1)
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