A clinical trial to study the effects of two drugs, propofol and thiopentone on airway changes in patients during general anaesthesia

Completed

Conditions: Calculus of gallbladder without cholecystitis, (2) ICD-10 Condition: O||Medical and Surgical,

Registration Number: CTRI/2023/11/060320

Lead Sponsor: Pt BD Sharma PGIMS, Rohtak

Brief Summary: The prospective study was conducted in the department of anaesthesia and critical care, PGIMS, Rohtak. Written informed consent were taken from patients included. Then assessment and comparison of airway mechanics was done during bag and mask ventilation using propofol and thiopentone as induction agents. Data were compiled and analysed with appropriate statistical test.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 90

Inclusion Criteria

ASA grade I & II.
Posted for elective surgery under general anaesthesia.

Exclusion Criteria

Anticipated difficult bag mask ventilation (history of snoring, obesity, large tongue, tonsillar hypertrophy, edentulous and presence of beard etc) and difficult airway (mouth opening less than 3 cm, MPG grade 3 and 4, TMD less than 6.5 cm, restricted neck movements and inability to extend the lower incisor beyond upper incisor) Pregnant patient BMI more than 30 kg/m2 Respiratory disease, increased risk of aspiration Requiring awake intubation History of allergy to study drugs Refusal to participate in the study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of static and dynamic compliance during bag mask ventilation after induction with thiopentone and propofol.	30 sec after achieving clinical end point of induction with thiopentone / \| propofol and till 30 sec after that (TI, TI1, TI2, TI3, TI4, TI5, TI6 i.e. 30s, 35s, 40s, 45s, 50s, 55s & 60s after induction respectively)

Secondary Outcome Measures

Name	Time	Method
To compare and assess	1. Peak inspiratory pressure (PIP) and plateau pressure (PP) at induction & after muscle

Trial Locations

Locations (1): Pt BD Sharma PGIMS Rohtak
🇮🇳
Rohtak, HARYANA, India
Pt BD Sharma PGIMS Rohtak
🇮🇳Rohtak, HARYANA, India
Dr Anurag Das
Principal investigator
7044071655
anuragdas019@gmail.com