The Effect of Restrictive Fluid and Vasopressin During Surgery of Burn Patients: a Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Vasopressin
- Conditions
- Burn Surgery
- Sponsor
- Hangang Sacred Heart Hospital
- Enrollment
- 158
- Locations
- 1
- Primary Endpoint
- Intraoperative blood loss
- Last Updated
- 7 years ago
Overview
Brief Summary
This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the restrictive group to further evaluate significant differences in intraoperative blood loos during burn surgery.
Detailed Description
This is a randomized double-blinded study to investigate the effect of fluid restriction and vasopressin on blood loss during surgery of the burn patients. The groups are designated as the control group and the restrictive group to further evaluate significant differences in intraoperative blood loss during the surgery.
Investigators
Hee Yeong Kim
Assistant Professor
Hangang Sacred Heart Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Restrictive group
Intervention: administration of vasopressin 0.01 - 0.04 U/min after induction of anesthesia. Intraoperative fluid management: administration of 2-4 ml/kg/hr of crystalloid solution.
Intervention: Vasopressin
Outcomes
Primary Outcomes
Intraoperative blood loss
Time Frame: At the end of the surgery, approximately 3 hrs
Comparison of the amounts of estimated blood loss in the two groups.
Secondary Outcomes
- Intraoperative red blood cell transfusion(At the end of the surgery, approximately 3 hrs)
- Postoperative pulmonary complication(Within 7 postoperative days)
- Postoperative cardiovascular complication(Within 7 postoperative days)
- Postoperative renal complication(Within 7 postoperative days)