Contextual Associations During Episodic Recall of Everyday or Virtual Reality
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 95
- 试验地点
- 2
- 主要终点
- BOLD cerebral response to contextual recall in medial temporal lobe
研究概览
简要总结
The project is dedicated to development of new paradigms to investigate memory and attention in the rich and realistic environments. The investigator will use modern interactive digital technologies for encoding complex episodes either using mobile phone technology in everyday life or using a virtual reality life-like simulation.
He aims to characterize the role of the medial temporal lobe and prefrontal cortex during recall of naturalistic episodic experiences, using functional neuroimaging (fMRI) in healthy participants. The secondary aim is assess how the allocation of attention during memory encoding contribute to mechanisms of the subsequent recall. He will achieve this by monitoring gaze direction during encoding and by analyzing the retrieval data as a function of the elements that participants attended / fixated during encoding.
The protocol will involve, first, behavioral testing of memory performance with encoding in the real-life or in virtual reality, followed by the main hypothesis testing phase when fMRI will be used to measure brain activity during retrieval.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Possession a Smartphone compatible with GPS 3-rd generation and exploitation system Android 4.2 with user-activated geolocation (for mobile phone studies).
- •Able to navigate in virtual reality with a help of the keyboard (for virtual reality studies).
- •Not using glasses.
- •All subjects will give their written consent for participation in the study.
- •They will be right-handed
- •They will have French social coverage.
排除标准
- •Previous neurologic or psychiatric disease.
- •Cognitive deficits restricting understanding of the tasks.
- •Pregnant or breath-feeding women.
- •Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty.
- •Subjects currently participating in other study.
- •Additional exclusion criteria for an fMRI recording
- •Neurologic, cardiac electrostimulation or defibrillator.
- •Cardiac prostheses
- •Intracranial clips or clamps
- •Cerebrospinal fluid disorders
- •Metal particles in the eyes
- •Metal dental or articular prostheses
- •Diffusion pomp or other infusion system
- •Claustrophobia
- •Head tattoo , makeup, hair gel
结局指标
主要结局
BOLD cerebral response to contextual recall in medial temporal lobe
时间窗: up to 1 week after the end of the encoding session
After spatial preprocessing of individual series of EPI fMRI images, normalization and smoothing as suggested for SPM analysis, the successful and failed contextual recall will be modeled and convolved with canonical HRF function. The GLM will be estimated according to the algorithm of SPM, the significance threshold will be p\<0.05 FWE within the regions of interest. Our hypothesis will be confirmed by activation of medial temporal lobe and prefrontal cortex in contextual recall, congruent contextual cueing and recall of episodes when targets were semantically congruent with the context at encoding.
BOLD cerebral response to contextual recall in prefrontal cortex
时间窗: up to 1 week after the end of the encoding session
After spatial preprocessing of individual series of EPI fMRI images, normalization and smoothing as suggested for Statistical Parametric Mapping (SPM) analysis, the successful and failed contextual recall will be modeled and convolved with canonical HRF function. The GLM will be estimated according to the algorithm of SPM, the significance threshold will be p\<0.05 Family-wise error (FWE) within the regions of interest. Our hypothesis will be confirmed by activation of medial temporal lobe and prefrontal cortex in contextual recall, congruent contextual cueing and recall of episodes when targets were semantically congruent with the context at encoding.
次要结局
- Pattern of gaze fixation during episodic encoding and cerebral activity during recall(up to 1 week after the end of the encoding session)