Proprioceptive Neuromuscular Facilitation Combined With Core Strengthening Exercise in Guillain Barre Syndrome Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Balance
研究概览
简要总结
This randomized controlled trial will evaluate the effectiveness of proprioceptive neuromuscular facilitation combined with core strengthening exercises in Guillain barre syndrome patients on balance, strength and ADLS. A total of 32 participants will be recruited using purposive sampling and randomly assigned into two groups through the sealed envelope method. Balance will be assessed using berg balance scale, strength will be measured by MMT and ADLS will measure by berthal index at baseline and after completion of the intervention participants in the experimental group will receive PNF + core strengthening exercise four times in week for eight weeks, and conventional physical therapy will perform on control group .
详细描述
Guillain-Barré Syndrome (GBS) is an acute immune-mediated inflammatory polyneuropathy characterized by rapidly progressive muscle weakness, diminished or absent deep tendon reflexes, sensory disturbances, impaired balance, and functional limitations in activities of daily living (ADLs). Although most patients recover gradually following the acute phase, many continue to experience persistent muscle weakness, impaired postural control, reduced trunk stability, and decreased functional independence during the subacute stage. Early rehabilitation plays a vital role in maximizing neurological recovery and improving functional outcomes.
Conventional physiotherapy is considered a standard rehabilitation approach for patients with subacute GBS and typically includes range of motion exercises, muscle strengthening, balance training, gait training, and functional mobility exercises. However, there is limited evidence regarding the additional benefits of combining Proprioceptive Neuromuscular Facilitation (PNF) with core strengthening exercises in this population.
Proprioceptive Neuromuscular Facilitation is a therapeutic approach that facilitates neuromuscular control through diagonal movement patterns, proprioceptive input, and manual resistance to improve muscle activation, coordination, strength, and motor function. Core strengthening exercises target the muscles of the trunk and pelvis, enhancing postural stability, balance, and functional movement, which are essential for regaining independence after neurological impairment.
This randomized controlled trial aims to evaluate the effectiveness of combining PNF with core strengthening exercises in patients with subacute Guillain-Barré Syndrome. A total of 32 participants meeting the eligibility criteria will be randomly allocated into two equal groups (16 participants per group). The experimental group will receive PNF techniques in combination with core strengthening exercises in addition to conventional physiotherapy, whereas the control group will receive conventional physiotherapy alone.
Outcome measures will be assessed at baseline, after four weeks, and after eight weeks of intervention. Primary outcomes include balance, muscle strength, and activities of daily living, assessed using the Berg Balance Scale (BBS), Manual Muscle Testing (MMT), and the Barthel Index (BI), respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •participants diagnosed with Guillain Barré Syndrome (GBS) based on neurological criteria
- •At the subacute or recovery stage of GBS, meaning within two to 12 weeks from disease onset
- •Age ranges from 18 to 45 years
- •Gender does not matter; both males and females can participate
- •Medical stability of the patient and being medically cleared to engage in intensive rehabilitation by a physical Ability to give informed consent
排除标准
- •Patients with cognitive disabilities and those who cannot follow commands
- •Patients with unstable heart and breathing rates and other systemic disease
- •Patients refusing to give their informed consent
- •Presence of musculoskeletal problems with balance problems (recent fractures, arthritis)
研究组 & 干预措施
PNF + core strengthening exercise
Participants in the experimental group will receive Proprioceptive Neuromuscular Facilitation (PNF) combined with core strengthening exercises versus conventional physiotherapy. The intervention will be administered according to the study protocol over 4 times in week for 8-week period.
干预措施: Proprioceptive neuromuscular facilitation combined with core strengthening exercise (Behavioral)
conventional physical therapy
Participants in the control group will receive conventional physiotherapy according to the standard rehabilitation protocol for patients with subacute Guillain-Barré Syndrome over 4 time per week for 8-week period.
干预措施: conventional physiotherapy (Behavioral)
结局指标
主要结局
Balance
时间窗: Baseline, week 4 and week 8
Balance was assessed using the Berg Balance Scale (BBS) . The Berg Balance Scale is a 14-item clinical scale that measures static and dynamic balance. Scores range from 0 to 56, with higher scores indicating better balance and functional performance.
muscle strength
时间窗: Baseline, week 4 and week 8
Muscle strength was assessed using the Medical Research Council (MRC) Manual Muscle Testing scale. Muscle strength is graded from 0 to 5, where 0 indicates no muscle contraction and 5 indicates normal muscle strength. Higher scores indicate better muscle strength.
Activities of Daily living (ADL)
时间窗: Baseline , week 4 and week 8
Activities of daily living were assessed using the Barthel Index (BI). The Barthel Index measures independence in activities of daily living. Scores range from 0 to 100, with higher scores indicating greater functional independence.
次要结局
未报告次要终点
研究者
Rida
PRS Administrator
University of Lahore