Adherence to ARV Treatment and Its Effects on Medium Run Socio-Economic Outcomes: Evidence From Western Kenya
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Georgetown University
- Enrollment
- 720
- Locations
- 1
- Primary Endpoint
- MEMS Adherence
Study Overview
Brief Summary
The purpose of proposed research is to implement a randomized study that will allow us to understand and address a number of key barriers to patient adherence as well as study the effects of better adherence on health and socio-economic outcomes.
Detailed Description
Several studies have shown that proper adherence to treatment regimens is essential for the effectiveness of ARV therapy (e.g Wools-Kaloustian et al. 2006). There is also evidence in that in some treatment programs in Africa, adherence rates are not always high (Gill et al. 2005). Even in settings where adherence levels are found to be high, numerous factors have been identified as being relevant, although the causal effects are unknown (Castro, 2006). As ARV treatment programs are scaled up in Africa, it is essential to understand the socio-economic determinants of adherence to ARV treatment, as well as the impact of interventions to support high levels of adherence. A secondary objective of this study is to understand the socio-economic impacts of higher adherence.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Factorial
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients who had been on ARV therapy at the Chulaimbo Rural Health Center for a maximum of three months and providing consent to participate in the study.
Exclusion Criteria
- •Patients who had been on ARV therapy for more than 3 months.
Arms & Interventions
Weekly SMS, brief message
Weekly SMS received on Monday at 12 noon
Intervention: Short Message Services to Support ARV therapy adherence (Behavioral)
Control Group
Receives a phone, but no messages.
Intervention: Short Message Services to Support ARV therapy adherence (Behavioral)
Daily SMS, Brief message
Receive daily brief message at 12 noon: "This is your reminder"
Intervention: Short Message Services to Support ARV therapy adherence (Behavioral)
Daily SMS, Long Message
Receive a daily long message at 12 noon: "This is your reminder + encouragement"
Intervention: Short Message Services to Support ARV therapy adherence (Behavioral)
Weekly SMS, Long Message
Weekly message sent at 12 noon on Mondays: "This is your reminder + encouragement"
Intervention: Short Message Services to Support ARV therapy adherence (Behavioral)
Outcomes
Primary Outcomes
MEMS Adherence
Time Frame: 12 months follow up
Secondary Outcomes
- Frequency/incidence of ARV treatment interruptions(12 months follow up)