Diagnostic Performance of an Aspergillus-specific Nested PCR Assay in Cerebrospinal Fluid Samples
- Conditions
- Focus: Immunocompromised Individuals at High Risk of Aqcuiring Invasive Aspergillosis
- Registration Number
- NCT01614145
- Lead Sponsor
- Heidelberg University
- Brief Summary
Multicentre, diagnostic study evaluating the performance of an aspergillus-specific PCR in cerebrospinal fluid samples of immunocompromised patients for identification of central nervous system aspergillosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Host factors
- Informed consent
Exclusion Criteria
- none
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Test sensitivity one year
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie Aspergillus detection in cerebrospinal fluid using nested PCR assays?
How does Aspergillus-specific nested PCR compare to galactomannan testing in diagnosing CNS aspergillosis in immunocompromised patients?
Which biomarkers correlate with PCR assay sensitivity for central nervous system aspergillosis in hematopoietic stem cell transplant recipients?
What adverse events are associated with Aspergillus-specific PCR testing in cerebrospinal fluid samples and how are they managed?
Are there alternative molecular diagnostic approaches to nested PCR for detecting fungal pathogens in cerebrospinal fluid of immunocompromised individuals?
Trial Locations
- Locations (3)
Freiburg University Hospital
🇩🇪Freiburg, Baden-Würrtemberg, Germany
Mannheim University Hospital
🇩🇪Mannheim, Baden-Würrtemberg, Germany
Frankfurt (Oder) General Hospital
🇩🇪Frankfurt (Oder), Brandenburg, Germany
Freiburg University Hospital🇩🇪Freiburg, Baden-Würrtemberg, Germany