The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Markers of immune activation and inflammation
研究概览
简要总结
Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap. The goal of this observational study is to address this knowledge gap by looking at the role of menopause on cardiovascular disease risk factors such as insulin resistance, hypertension, hyperlipidemia, and carotid atherosclerosis using previously collected data. The investigators will look at underlying causes for cardiovascular diseases worsening in menopausal women with HIV by looking at the role of increased inflammation in the body and whether this is altered by weight. The investigators achieve this by enrolling participants who are willing to undergo a whole body MRI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •90 non-pregnant women with HIV (approximately 30 in each menopausal phase) from the San Francisco MWCCS site.
排除标准
- •Women who are not virally suppressed (HIV RNA >200 copies/mL)
- •Women who are not on antiretroviral therapy
- •Women who have a history of hysterectomy or oophorectomy
- •Women who are receiving treatment for active cancer or tuberculosis
研究组 & 干预措施
MACS-WIHS Combined Cohort Study
干预措施: Whole body MRI (Diagnostic Test)
结局指标
主要结局
Markers of immune activation and inflammation
时间窗: These markers will be measured from blood work collected at the scheduled study visit [Day 1] close to the time of MRI and thus will be collected at only one time point.
sCD14 (monocyte activation), sCD163 (M2 macrophage activation), CRP (inflammation), IL-6 (inflammation), IP-10 (interferon-inducible protein), TNFα (inflammation), MCP-1 (inflammation), sTNFRI \& RII (inflammation). There are no units as they will be normalized based upon their interquartile range.
次要结局
未报告次要终点
