Impact of Adding Midzolam to Bupavicaine 0.5% in Regional Spinal Anaesthesia on Maternal Middle Cerebral Artery Velocimetry in Parturients With Severer Preeclampsia

Not Applicable

• Conditions: Midazolam in Preeclamptic Patients
• Interventions: Drug: intrthecl midazolam

• Registration Number: NCT04283110
• Lead Sponsor: Minia University

Brief Summary

Trial to use GABA mimetic action of midazolam to ameliorate the severe preeclampsia induced neuronal excitotoxicity using middle cerebral artery transcranial doppler resisitive vasculer indices to evaluate . Secondery goal is to study end organ injury

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-12
• Status Verified: 2020-02
• Primary Completion: 2020-02-17
• Study First Submitted: 2020-02-21
• Study First Submitted QC: 2020-02-21
• Last Update Submitted: 2020-02-21
• Study First Posted: 2020-02-25
• Last Update Posted: 2020-02-25
• Study Completion: 2020-04-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• All parturients with severe preeclampsia for urgent C.S

Exclusion Criteria

• Ladies refusal to participate. Refusal to have spinal anesthsia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Midazolam group	intrthecl midazolam	Midazolam group will receive 1 mg intrathecal midazolam once during induction for anethesia

Primary Outcome Measures

Name	Time	Method
Measuring Pulsatality index and resistive index of maternal middle cerebral artery	2 months	Resistive vasculer indices outcome after intrthecal midazolam injection

Trial Locations

Locations (1)

Elminia university; 🇪🇬 Cairo, Egypt