Study of Heat and Intravenous Fluids for Exogenous Rewarming (SHIVER)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 主要终点
- Rate of rewarming
研究概览
简要总结
The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with either shivering alone, warmed iv fluids (IVF), or water perfusion pads applied to the hands and feet. The investigators hypothesize that both heated IVF and water perfusion pads to the arteriovenous anastomoses (AVAs) will prove to provide significantly superior rewarming rates than shivering alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any healthy male or female over 18 years of age
排除标准
- •No heart/blood pressure/cholesterol medications.
- •No history of Raynaud's disease or any other condition (including asthma) that could be aggravated by cold-water immersion
研究组 & 干预措施
Shivering only
Pt placed in sleeping bag and warmed by shivering only
Warmed IV fluids
2 Liter of 42 degree celsius normal saline
干预措施: Warmed IV fluids (Other)
Warmed perfusion pads
Warmed perfusion pads placed to palms and soles to rewarm through arteriovenous anastomoses
干预措施: Warmed perfusion pads (Other)
结局指标
主要结局
Rate of rewarming
时间窗: 60 minutes
Track to rate of rewarming of each arm
次要结局
未报告次要终点
研究者
Grant S Lipman
Principle Investigator
Stanford University