Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Pupil Diameter
研究概览
简要总结
This study investigates the capacity of non-invasive vagus nerve stimulation, applied at the ear, to alter to measures of locus coeruleus output pupil diameter and EEG alpha power. Non-invasive alteration in locus coeruleus output is of interest in regard to basic science and has potential clinical implications in a number of conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, 18 years of age or older.
排除标准
- •self-report of mood disorders, prescription and non-prescription drug use which includes stimulants including caffeine and nicotine
研究组 & 干预措施
Active Stimulation 0.5
0.5mA, 30Hz intermittent transdermal vagus nerve stimulation of the auricle vagus. Stimulation 30 second on/30 seconds off for five cycles.
干预措施: Transdermal Vagus Nerve Stimulation (tVNS) (Device)
Lobe Control
0.5mA, 30Hz intermittent transdermal vagus nerve stimulation of the earlobe. Stimulation 30 second on/30 seconds off for five cycles.
干预措施: Transdermal Vagus Nerve Stimulation (tVNS) (Device)
Sham Stimulation
0.5mA, 5Hz intermittent transdermal vagus nerve stimulation of the auricle vagus. Stimulation 30 second on/30 seconds off for five cycles.
干预措施: Transdermal Vagus Nerve Stimulation (tVNS) (Device)
Nonstimulation
Placement of electrode without any stimulation.
干预措施: Transdermal Vagus Nerve Stimulation (tVNS) (Device)
结局指标
主要结局
Pupil Diameter
时间窗: Within single one hour session
Pupil diameter is measured via camera.
EEG Alpha power.
时间窗: Within single one hour session
Alpha power will be determined from EEG.
次要结局
未报告次要终点