Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation

Not Applicable

Active, not recruiting

• Conditions: Electroencephalography; Pupil Diameter; no Condition

• Registration Number: NCT04455295
• Lead Sponsor: Arkansas Tech University

Brief Summary

This study investigates the capacity of non-invasive vagus nerve stimulation, applied at the ear, to alter to measures of locus coeruleus output pupil diameter and EEG alpha power. Non-invasive alteration in locus coeruleus output is of interest in regard to basic science and has potential clinical implications in a number of conditions.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-29
• Study First Submitted QC: 2020-06-29
• Study First Posted: 2020-07-02
• Study Start: 2020-09-01
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-23
• Last Update Posted: 2024-02-28
• Primary Completion: 2025-06-01
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• Healthy, 18 years of age or older.

Exclusion Criteria

• self-report of mood disorders, prescription and non-prescription drug use which includes stimulants including caffeine and nicotine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pupil Diameter	Within single one hour session	Pupil diameter is measured via camera.
EEG Alpha power.	Within single one hour session	Alpha power will be determined from EEG.

Trial Locations

Locations (1)

Arkansas Tech University; 🇺🇸 Russellville, Arkansas, United States