Skip to main content
MedPathMedPath Home
Clinical Trials/NCT03442907
NCT03442907
Completed
N/A

Intraoperative Blood Pressure Management Based on the Individual Blood Pressure Profile: Impact on Postoperative Organ Function

Universitätsklinikum Hamburg-Eppendorf1 site in 1 country368 target enrollmentMarch 1, 2018
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsBlood PressureIntraoperative HypotensionPostoperative Complications

Overview

Phase
N/A
Intervention
Not specified
Conditions
Blood Pressure
Sponsor
Universitätsklinikum Hamburg-Eppendorf
Enrollment
368
Locations
1
Primary Endpoint
Composite endpoint: Incidence of POCD or delirium
Status
Completed
Last Updated
5 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The aim of this research project is to find out whether a personalized definition of the lower blood pressure threshold based on the individual blood pressure profile by means of preoperative 24-hour blood pressure measurement can reduce organ damage (brain, kidney, heart) through reduced blood flow during surgery.

Registry
clinicaltrials.gov
Start Date
March 1, 2018
End Date
January 31, 2020
Last Updated
5 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • •Pregnancy
  • •Emergency procedures
  • •Surgery requiring controlled hypotension (e.g., aneurysm)
  • •Cerebrovascular events in the past medical history
  • •Patients of cardiac surgery, vascular surgery, neurosurgery, and transplantation surgery
  • •Pre-existing dementia (anamnesis)
  • •kidney transplant
  • •dialysis-dependent renal insufficiency (KDIGO criteria)
  • •no patient consent
  • •failure to meet the inclusion criteria

Outcomes

Primary Outcomes

Composite endpoint: Incidence of POCD or delirium

Time Frame: 3rd-7th postoperative day

POCD is measured on the basis of a neuropsychological test battery and the delirium on the basis of the CAM-ICU test.

Secondary Outcomes

  • Kidney function(24, 48 and 72 hrs after surgery)
  • cardiac ischemia(6 hours after surgery)
  • length of hospital stay(30 days)
  • 30-day morbidity(30 days)
  • 30-day mortality(30 days)

Study Sites (1)

Loading locations...

Similar Trials

Completed
N/A
Perioperative Personalized Blood Pressure ManagementBlood PressureIntraoperative HypotensionPostoperative Complications
NCT04894045Universitätsklinikum Hamburg-Eppendorf105
Recruiting
N/A
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac SurgeryIntraoperative Arterial Hypotension
NCT05336864University Hospital, Basel, Switzerland650
Completed
N/A
Individual Blood Pressure Optimization Based on Cerebral Autoregulation After Implantation of Continuous-flow LVADHeart-Assist DevicesHeart Failure
NCT03093012Baylor College of Medicine69
Recruiting
N/A
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）TumorStroke
NCT06711432Zhejiang Cancer Hospital214
Unknown
N/A
A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma PatientsHemorrhagic ShockTraumaWounds, PenetratingShock, TraumaticMultiple Trauma
NCT00459160Baylor College of Medicine271