The Clinical Study of the Poorly Differentiated Head and Neck Squamous Cell
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 主要终点
- survival rate
研究概览
简要总结
Head and neck Squamous Cell Carcinoma (HNSCC) is one of the most common head and neck malignant tumors .Investigators found that several patients with early TNM stage and poor differentiated HNSCC had poor prognosis, yet someone with advanced TNM stage and well differentiated HNSCC had good prognosis. Hence, Investigators suggested that prognosis factors and survival rates probably related to the differentiation of HNSCC, and prognosis factor of poorly differentiated HNSCC were rare discussed and controversy. Investigating the prognostic factors of poorly differentiated HNSCC is undoubtedly crucial.
详细描述
Head and neck Squamous Cell Carcinoma (HNSCC) is one of the most common head and neck malignant tumors. Investigators found that several patients with early TNM stage and poor differentiated HNSCC had poor prognosis, yet someone with advanced TNM stage and well differentiated HNSCC had good prognosis. Hence, Investigators suggested that prognosis factors and survival rates probably related to the differentiation of HNSCC, and prognosis factor of poorly differentiated HNSCC were rare discussed and controversy. Investigating the prognostic factors of poorly differentiated HNSCC is undoubtedly crucial.
About this study ,inclusion criteria were the following parts:
the patients of poor differentiated HNSCC ; T1-4aN0-2M0; pathological examination: poor differentiated squamous cell carcinoma; initial treatment(primary, without surgery, radiotherapy and chemotherapy); range:18-70 years old; KPS>80; hemogram and the function of main organ such as heart, lung, liver and kidney were normal; having the endoscopy, CT and MRI before formed into different groups; sign the informed consent file, good compliance.
AND the exclusion criteria were:
uncontrollable epileptic seizure, disorder of central nervous system or unconsciousness cause by psychosis; serious and uncontrollable infection; main organ system failure (including heart ,lung ,liver and kidney); reject training; high and moderate differentiated squamous cell carcinoma
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of poor differentiated HNSCC ;
- •Patients within the stage of T1-4aN0-2M0;
- •The pathological examination of the patients show poor differentiated squamous cell carcinoma;
- •Patients with initial treatment(primary, without surgery, radiotherapy and chemotherapy);
- •18-70 years old;
- •Hemogram and the function of main organ such as heart, lung, liver and kidney were normal
- •Having the endoscopy, CT and MRI Signed the informed consent file, good compliance.
排除标准
- •Uncontrollable epileptic seizure, disorder of central nervous system or unconsciousness cause by psychosis;
- •Serious and uncontrollable infection;
- •Main organ system failure (including heart ,lung ,liver and kidney); reject training;
- •High and moderate differentiated squamous cell carcinoma
结局指标
主要结局
survival rate
时间窗: 3 years
次要结局
未报告次要终点
研究者
Zhigang Huang
Capital Medical University
Beijing Tongren Hospital