Effect of Intra-ovarian Injection of Autologous Platelet Rich Plasma on Ovarian Reserve Parameters and Intra Cytoplasmic Sperm Injection Outcomes in Patients With Diminished Ovarian Reserve
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- number of retrieved oocytes
研究概览
简要总结
The aim of this study is to evaluate the efficacy of intra ovarian injection of autologous platelet rich plasma on ovarian reserve parameters and ICSI outcomes in poor ovarian reserve.
详细描述
fifty_six infertile women suffering from poor ovarian reserve &following up at IVF Unit of Beni_suef University hospital. , and they fulfilled inclusion and exclusion criteria. they will be classlfied into two groups: Group A (study group) (involve 28 patient ):will be injected intra ovarian by platelet rich plasma Group B (control group) (involve 28 patient): will not be injected intra ovarian by platelet rich Plasma
The researcher will introduce himself to all participants included in this study and requested that they participate after explaining the purpose of the study. All participants will be given detailed information about the study's goal and predicted advantages. All participants will give their informed verbal agreement, and the data will be kept confidential. All patients will be subjected to:
Complete history was taken with special emphasis on:
Personal ,past,family&surgical history. Menstrual historyObstetric history
Clinical examination:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women under the age of
- •have been infertile for more than a year
- •have had at least one previous unsuccessful (or cancelled) IVF cycle.
- •having one of the criteria of poor ovarian response including anti mullerian hormone (AMH) level <1.1 ng /ml ,the antral follicle count of two ovaries in vaginal ultrasound <7 .
排除标准
- •pregnancy(ruled out and documented before PRP injection) . Hydrosalpinex,uterine malformations and abnormal uterine cavity.
- •Partner with severe male factor
- •Ongoing malignancy.
- •Chronic pelvic pain
- •A history of major lower abdomen surgeries that resulted in pelvic adhesions.
结局指标
主要结局
number of retrieved oocytes
时间窗: 1 month of induction for ICSI trial
number of oocytes obtained in ovum pick up
次要结局
未报告次要终点
研究者
Sara Abdallah Mohamed Salem
principle investigator/Lecturer of Gynecology and obstetrics Faculty of medicine Beni-Suef University
Beni-Suef University