Motor Recovery of Stroke Patients Based on Electroencephalogram-functional Magnetic Resonance Imaging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Motor Neuropathy
- Sponsor
- Health Science Center of Xi'an Jiaotong University
- Enrollment
- 111
- Locations
- 1
- Primary Endpoint
- Fugl-Meyer scores (T1)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
Detailed Description
A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points.
Investigators
Wentao Zeng
PhD candidate
Health Science Center of Xi'an Jiaotong University
Eligibility Criteria
Inclusion Criteria
- •Age above 18 and below 75 years
- •Motor impairment in National Institutes of Health Stroke Scale
- •7-14 days since stroke attack
- •First-ever ischemic stroke
Exclusion Criteria
- •Motor impairment induced by non-stroke aetiology
- •Claustrophobia; recognition disorder
- •History of other severe central nervous system diseases
- •Any signs unfit for MRI/EEG scan
Outcomes
Primary Outcomes
Fugl-Meyer scores (T1)
Time Frame: 6 weeks since stroke
a scale widely used to evaluate one's motor impairment
Fugl-Meyer scores (T0)
Time Frame: 7-14 days since stroke
a scale widely used to evaluate one's motor impairment
Fugl-Meyer scores (T2)
Time Frame: 12 weeks since stroke
a scale widely used to evaluate one's motor impairment
Fugl-Meyer scores (T3)
Time Frame: 72 weeks since stroke
a scale widely used to evaluate one's motor impairment
Secondary Outcomes
- Neuroimage features based on EEG-fMRI (T3)(72 weeks since stroke)
- Neuroimage features based on EEG-fMRI (T0)(7-14 days since stroke)
- Neuroimage features based on EEG-fMRI (T1)(6 weeks since stroke)
- Neuroimage features based on EEG-fMRI (T2)(12 weeks since stroke)