The Efficacy of Intraoperative Ketamine in Patients Undergoing Robot-assisted Thyroidectomy
Overview
- Phase
- Not Applicable
- Intervention
- NS infusion
- Conditions
- Thyroid
- Sponsor
- Seoul National University Hospital
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Pain at 24 hour postoperatively
- Last Updated
- 12 years ago
Overview
Brief Summary
In this prospective double-blinded study, The investigators compared acute postoperative pain and rescue analgesic demand during postoperative period after robot thyroidectomy between ketamine and placebo groups.
Detailed Description
Robot-assisted endoscopic thyroidectomy has been popularized due to cosmetic advantages. Despite small incisions, robot thyroidectomy did not offer satisfactory reduction in postoperative pain compared to open thyroidectomy. Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor blocker and takes some attractive advantages in terms of pain control. When low dose ketamine is perioperatively administrated, opioid sparing effect during postoperative period is reported in various surgical procedures such as spine, thoracic, and gynecologic surgery. Ketamine's beneficial effect on postoperative pain has not been investigated in patients undergoing robot thyroidectomy. The investigators hypothesized that perioperative ketamine administration can reduce acute postoperative pain after robot thyroidectomy and the incidence of chronic pain hypoesthesia on anterior chest at 3 months after surgery.
Investigators
Hee-Pyoung Park
Associate professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for robot-assisted thyroidectomy
- •ASA I-III
Exclusion Criteria
- •Patients with renal dysfunction
- •Patients with hepatic dysfunction
- •Patients with neurologic dysfunction
- •Patients with the history of drug addiction
- •Patients with chronic pain
- •Patients who are allergic to ketamine
- •Patients with increased ocular or intracranial pressure
- •Patients with the risk of aspiration
Arms & Interventions
C group
In C group, NS infusion will be done intraoperatively.
Intervention: NS infusion
KET group
In KET group, ketamine infusion will be done intraoperatively(0.25 mg/kg bolus injection following 100 mcg/kg/hr till the end of surgery).
Intervention: Ketamine infusion
Outcomes
Primary Outcomes
Pain at 24 hour postoperatively
Time Frame: at 24 hour postoperatively
Pain at 24 hour postoperatively will be evaluates using 11 point scale (0:no pain, 10:worst imaginable)
Secondary Outcomes
- Chronic pain at 3 month after surgery(At 3 month after surgery)
- Analgesic requirements for 24 hours after surgery(at 24 hours postoperatively)
- Pain at 3, 6, 12, 48 and 72 hour postoperatively(at 3, 6, 12, 48 and 72 hour postoperatively)
- Time to the first analgesics postoperatively(At 24 hours postoperatively)