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Clinical Trials/DRKS00030346
DRKS00030346
Completed
未知

Investigation of matrix metalloproteinase-9 levels in dental pulp blood as a marker for the inflammatory state of the pulp tissue - a prospective clinical pilot study

Poliklinik für ZahnerhaltungskundeUniversitätsklinikum Heidelberg0 sites44 target enrollmentStarted: October 25, 2022Last updated:
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ConditionsK02.1K02.5Caries of dentineCaries with pulp exposure

Overview

Phase
未知
Status
Completed
Sponsor
Poliklinik für ZahnerhaltungskundeUniversitätsklinikum Heidelberg
Enrollment
44
OverviewStudy DesignEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional
Allocation
Non-randomized controlled study
Masking
Open (masking not used)

Eligibility Criteria

Ages
12 Years to one (—)
Sex
All

Inclusion Criteria

  • •Male and female patients of the age \= 12 years
  • •\- Patients from the Department of Conservative Dentistry at Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg or from one of the cooperating trial centres
  • •\- Present declaration of consent of the patient to participate in the study; in the case of underage patients, the consent of the legal guardian/legal representative must also be present
  • •\- Adult patients must be able to give consent
  • •\- Teeth in which (the clearly vital) pulp of a tooth with a caries extending into the pulp resulting in pulp exposure during caries excavation.
  • •\- The pulp tissue of the treated tooth must be classified either as completely asymptomatic, reversibly inflamed (reversible pulpitis) or irreversibly inflamed (irreversible pulpitis).
  • •\- The tooth must be treatable and restorable under rubber dam isolation.
  • •\- The restoration of the tooth after partial pulpotomy and subsequent direct pulp capping with ProRoot MTA® using composite must be completed within 24 hours.

Exclusion Criteria

  • •\- Primary teeth
  • •\- Patients whose state of health is reduced to such an extent that they are not able to cope with the usual stress (e.g. immunocompromised patients)
  • •\- Patients for the period of their pregnancy
  • •\- Patients who have not yet reached the age of 12
  • •\- Patients who do not give their consent to participate in the study
  • •\- Patients who have taken antibiotics in the last four weeks
  • •\- Patients who have taken medicaments with a potential influence on the MMP\-9 level, e.g. bisphosphonates, statins, acetylsalicylic acid (exception is group 3, in which patients have taken the NSAID Ibuprofen)
  • •\- Teeth that have a longitudinal fracture at the time of the treatment with partial pulpotomy
  • •\- Teeth which, at the time of the treatment, showed bone loss down to the apical third of the root, teeth with a perio\-endo\-lesion or teeth with a degree of mobility of 3
  • •\- Teeth that showed at the periapical radiograph a periapical index PAI\=2 at the day of the treatment (arm 1 and 2 with partial pulpotomy)

Investigators

Sponsor
Poliklinik für ZahnerhaltungskundeUniversitätsklinikum Heidelberg

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