Investigation of matrix metalloproteinase-9 levels in dental pulp blood as a marker for the inflammatory state of the pulp tissue - a prospective clinical pilot study

Poliklinik für ZahnerhaltungskundeUniversitätsklinikum Heidelberg0 个研究点目标入组 44 人开始时间: 2022年10月25日最近更新: 2024年8月19日

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•Male and female patients of the age = 12 years
•- Patients from the Department of Conservative Dentistry at Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg or from one of the cooperating trial centres
•- Present declaration of consent of the patient to participate in the study; in the case of underage patients, the consent of the legal guardian/legal representative must also be present
•- Adult patients must be able to give consent
•- Teeth in which (the clearly vital) pulp of a tooth with a caries extending into the pulp resulting in pulp exposure during caries excavation.
•- The pulp tissue of the treated tooth must be classified either as completely asymptomatic, reversibly inflamed (reversible pulpitis) or irreversibly inflamed (irreversible pulpitis).
•- The tooth must be treatable and restorable under rubber dam isolation.
•- The restoration of the tooth after partial pulpotomy and subsequent direct pulp capping with ProRoot MTA® using composite must be completed within 24 hours.

•- Primary teeth
•- Patients whose state of health is reduced to such an extent that they are not able to cope with the usual stress (e.g. immunocompromised patients)
•- Patients for the period of their pregnancy
•- Patients who have not yet reached the age of 12
•- Patients who do not give their consent to participate in the study
•- Patients who have taken antibiotics in the last four weeks
•- Patients who have taken medicaments with a potential influence on the MMP-9 level, e.g. bisphosphonates, statins, acetylsalicylic acid (exception is group 3, in which patients have taken the NSAID Ibuprofen)
•- Teeth that have a longitudinal fracture at the time of the treatment with partial pulpotomy
•- Teeth which, at the time of the treatment, showed bone loss down to the apical third of the root, teeth with a perio-endo-lesion or teeth with a degree of mobility of 3
•- Teeth that showed at the periapical radiograph a periapical index PAI=2 at the day of the treatment (arm 1 and 2 with partial pulpotomy)
•- Teeth that showed at the periapical radiograph a periapical index PAI>2 at the day of the treatment (arm 3 and 4 with root canal treatment). Teeth in which an internal or external tooth/root resorption is already evident at day of the treatment with partial pulpotomy,
•- Teeth that could not be assigned unequivocally to one of the four diagnostic groups after clinical and radiographic examination

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Poliklinik für ZahnerhaltungskundeUniversitätsklinikum Heidelberg