French National Observatory of the Patients With Non-small Cell Lung (NSCLC) and Molecular Testings
- Conditions
- Carcinoma, Non-Small-Cell LungKRAS Gene MutationALK Gene MutationBRAF Gene Mutation
- Registration Number
- NCT01700582
- Lead Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
- Brief Summary
The French National Cancer Institute (INCa) support a 28 hospital platforms network for molecular testing of cancer patients. These platforms routinely assess a panel of biomarkers in order to speed up access of French cancer patients to targeted therapies (commercially available or through clinical trials).
The objective of the BIOMARKERS-France study is to describe the epidemiological, clinical and molecular characteristics of these patients and their tumors and to assess the impact of these analyzes on their treatment (ie bio-guided therapy) as well as outcomes (response rate, progression free and overall survival).
- Detailed Description
The French National Cancer Institute (INCa) support a 28 hospital platforms network for molecular testing of cancer patients. These platforms routinely assess a panel of biomarkers in order to speed up access of French cancer patients to targeted therapies (commercially available or through clinical trials).
Regarding stage IV non-squamous NSCLC patients, 7 biomarkers are assessed including activating EGFR mutations, EML4-ALK translocation and EGFR T790M, KRAS, BRAF, HER2 and PI3KCA mutations. In 2012, up to 17 to 20,000 patients will be tested on this platform network.
The objective of the BIOMARKERS-France study is to describe the epidemiological, clinical and molecular characteristics of these patients and their tumors and to assess the impact of these analyzes on their treatment (ie bio-guided therapy) as well as outcomes (response rate, progression free and overall survival).
This study will collect, in a prospective way, data from a unique national cohort in order to guide future decisions regarding biomarker assessments (type? Number? Methods? Etc) in connexion with all the other research works currently ongoing in France.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17664
- Advanced Non-small cell lung cancer (NSLC)
- Biomarkers analysis on hospital platforms
- Histology other than NSLC
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method EGF-R gene mutation in nationwide cohort 1 Year Number of patients with EGF-R gene mutation
- Secondary Outcome Measures
Name Time Method BRAF gene mutation in nationwide cohort 1 year Number of patients with BRAF gene mutation
EML4-ALK translocation in nationwide cohort 1 year Number of patients with EML4-ALK translocation
PI3K gene mutation in nationwide cohort 1 year Number of patients with PI3K gene mutation
K-RAS gene mutation in nationwide cohort 1 year Number of patients with K-RAS gene mutation
HER2 gene mutation in nationwide cohort 1 year Number of patients with HER2 gene mutation
Trial Locations
- Locations (132)
Meaux - CH
🇫🇷Meaux, France
Orléans - CH
🇫🇷Orléans, France
Paris - Saint Louis
🇫🇷Paris, France
CH de la Côte Basque
🇫🇷Bayonne, France
Dax - CH
🇫🇷Dax, France
CHU d'Angers
🇫🇷Angers, France
Clinique Calabet - Centre de Radiothérapie et d'Oncologie
🇫🇷Agen, France
Clinique de l'Europe
🇫🇷Amiens, France
Auxerre - CH
🇫🇷Auxerre, France
CH d'Avignon
🇫🇷Avignon, France
Montpellier - CHRU
🇫🇷Montpellier, France
Nancy - Polyclinique Gentilly
🇫🇷Nancy, France
CHICAS Site de Gap
🇫🇷Gap, France
Jonzac - CH
🇫🇷Jonzac, France
La Roche Sur Yon - CH
🇫🇷La Roche Sur Yon, France
Lille - Hôpital Calmette
🇫🇷Lille, France
Mulhouse - CH
🇫🇷Mulhouse, France
Hôpital Laënnec - CHU de Nantes
🇫🇷Nantes, France
CH de Périgueux
🇫🇷Périgueux, France
Paris - hôpital Saint-Antoine
🇫🇷Paris, France
Hôpital du Val de Grâce
🇫🇷Paris, France
Nanterre - CH
🇫🇷Nanterre, France
Nevers - CH
🇫🇷Nevers, France
Nice - CAC
🇫🇷Nice, France
Hôpital Européen Georges Pompidou
🇫🇷Paris, France
Reims - CHU
🇫🇷Reims, France
Nantes - Centre René Gauducheau
🇫🇷Nantes, France
GH Paris Saint-Joseph
🇫🇷Paris, France
CHU
🇫🇷Poitiers, France
Hôpital Bichat - Claude - Bernard
🇫🇷Paris, France
Hôpital Tenon
🇫🇷Paris, France
Clinique Claude Bernard
🇫🇷Albi, France
CHU Côte de Nâcre
🇫🇷Caen, France
HIA Desgenettes
🇫🇷Lyon, France
Lyon - Hôpital Louis Pradel (Pneumologie)
🇫🇷Lyon, France
Pau - CH
🇫🇷Pau, France
Perpignan - Centre Catalan d'Oncologie
🇫🇷Perpignan, France
Perpignan - Ch
🇫🇷Perpignan, France
Saint-Nazaire - CH
🇫🇷Saint-Nazaire, France
Valenciennes - Clinique
🇫🇷Valenciennes, France
Suresnes - Hopital Foch
🇫🇷Suresnes, France
Hôpital Privé d'Antony
🇫🇷Antony, France
CHU Avicenne
🇫🇷Bobigny, France
CHIC
🇫🇷Aulnay-Sous-Bois, France
CHU Besancon - Pneumologie
🇫🇷Besancon, France
Blois - CH
🇫🇷Blois, France
Hôpital Ambroise Paré - Pneumologie
🇫🇷Boulogne, France
Hôpital Fleyriat
🇫🇷Bourg en Bresse, France
Hôpital de Briançon
🇫🇷Briançon, France
CH de Béziers
🇫🇷Béziers, France
Cahors - CH
🇫🇷Cahors, France
CH de Cannes
🇫🇷Cannes, France
Chambray Les Tours - Clinique Léonard de Vinci
🇫🇷Chambray Les Tours, France
CH de Chartres Hôpital Louis Pasteur
🇫🇷Chartres, France
Chevilly-Larue - CH
🇫🇷Chevilly-Larue, France
Hôpital de Cholet - Pneumologie
🇫🇷Cholet, France
Hôpital Percy-Armées - Pneumologie
🇫🇷Clamart, France
Hôpital Pasteur
🇫🇷Colmar, France
Clinique des Cèdres
🇫🇷Cornebarrieu, France
Créteil - CHI
🇫🇷Créteil, France
Denain - CH
🇫🇷Denain, France
Dijon - CAC
🇫🇷Dijon, France
Dijon - CHU
🇫🇷Dijon, France
Draguignan - CH
🇫🇷Draguignan, France
CH de Dreux
🇫🇷Dreux, France
Elbeuf - CH
🇫🇷Elbeuf, France
Epinal - CH
🇫🇷Epinal, France
Ermont - Clinique Claude Bernard
🇫🇷Ermont, France
Evreux - CH
🇫🇷Evreux, France
Flers - CH
🇫🇷Flers, France
CHRU Grenoble
🇫🇷Grenoble, France
Saint Omer - CHI
🇫🇷Helfaut, France
Le Havre - HPE
🇫🇷Le Havre, France
Le Mans - Centre Hospitalier
🇫🇷Le Mans, France
Le Mans - Clinique Victor Hugo
🇫🇷Le Mans, France
CH Dr Schaffner de Lens
🇫🇷Lens, France
CHU (Hôpital Calmette) - Pneumologie
🇫🇷Lille, France
Limoges - Hôpital du Cluzeau
🇫🇷Limoges, France
Liévin - polyclinique de Riaumont
🇫🇷Liévin, France
CH de Longjumeau
🇫🇷Longjumeau, France
Lorient - CHBS
🇫🇷Lorient, France
Clinique des 4 Pavillons
🇫🇷Lormont, France
Lyon - Clinique Mutualiste
🇫🇷Lyon, France
Clinique Mutualiste Eugène André
🇫🇷Lyon, France
Hôpital de la Croix Rousse
🇫🇷Lyon, France
Mantes La Jolie - CH
🇫🇷Mantes La Jolie, France
Marseille - Hôpital Sainte Marguerite
🇫🇷Marseille, France
Marseille - CRLCC
🇫🇷Marseille, France
Polyclinique du Parc
🇫🇷Maubeuge, France
Metz - CHR
🇫🇷Metz, France
Metz - Clinique Claude Bernard
🇫🇷Metz, France
Metz - Belle Isle
🇫🇷Metz, France
Mont de Marsan - CH
🇫🇷Mont de Marsan, France
Montpellier - Clinique Clémentville
🇫🇷Montpellier, France
Moulins - CH
🇫🇷Moulins, France
CHU Nancy
🇫🇷Nancy, France
Narbonne - Polyclinique Le Languedoc
🇫🇷Narbonne, France
Neuilly - Hôpital Américain de Paris
🇫🇷Neuilly, France
Nîmes - Clinique Valdegour
🇫🇷Nîmes, France
Lyon Sud
🇫🇷Pierre Bénite, France
Clinique Saint Jean du Languedoc
🇫🇷Toulouse, France
Pontoise - CH
🇫🇷Pontoise, France
Senlis - CH
🇫🇷Senlis, France
Reims - CRLCC
🇫🇷Reims, France
Rennes - CHU
🇫🇷Rennes, France
CHG de Roanne
🇫🇷Roanne, France
Rodez - CH
🇫🇷Rodez, France
Roncq - Clinique Saint-Roch
🇫🇷Roncq, France
Roubaix - CH
🇫🇷Roubaix, France
Rouen - CHU
🇫🇷Rouen, France
Saint Brieuc - CHG
🇫🇷Saint Brieuc, France
Saint-Malo - CH
🇫🇷Saint-Malo, France
Centre Frederic Joliot
🇫🇷Rouen, France
Saint Nazaire - Centre Etienne Dolet
🇫🇷Saint Nazaire, France
Saint Priest en Jarez - ICL
🇫🇷Saint Priest en Jarez, France
Saint Quentin - CH
🇫🇷Saint Quentin, France
Saverne - CH
🇫🇷Saverne, France
Toulon - CHI
🇫🇷Toulon, France
Toulon - HIA
🇫🇷Toulon, France
Verdun - CHG
🇫🇷Verdun, France
Strasbourg - NHC
🇫🇷Strasbourg, France
Thonon les bains
🇫🇷Thonon les bains, France
Tours - CHU
🇫🇷Tours, France
Troyes - CH
🇫🇷Troyes, France
Toulouse - CHU Larrey
🇫🇷Toulouse, France
Vesoul - CHI
🇫🇷Vesoul, France
CHI de la Haute-Saône - Pneumologie
🇫🇷Vesoul, France
Vienne - CH
🇫🇷Vienne, France
Villejuif - Institut Gustave Roussy
🇫🇷Villejuif, France
Clinique Mutualiste Les Portes du Sud
🇫🇷Vénissieux, France
Toulouse - Clinique Pasteur
🇫🇷Toulouse, France
Paris - Curie
🇫🇷Paris, France