fMRI Based Neurofeedback as a Treatment Method for Depression

Cardiff University2 sites in 1 country43 target enrollmentMarch 2012

ConditionsUnipolar Depression

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Unipolar Depression
Sponsor: Cardiff University
Enrollment: 43
Locations: 2
Primary Endpoint: Change from Baseline in Hamilton Depression Rating Scale (HDRS) score at the end of intervention (after 5th session)
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of the study is to investigate whether neurofeedback delivered via functional magnetic resonance imaging signals can be used to train depressed patients to self-regulate emotion networks and whether this improves clinical symptoms.

Registry

clinicaltrials.gov

Start Date

March 2012

End Date

September 2014

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Cardiff University

Responsible Party

Principal Investigator

David Linden

Professor of Translational Neuroscience

Cardiff University

Eligibility Criteria

Inclusion Criteria

•major depressive disorder (MDD) diagnosis
•stable antidepressant dose medication

Exclusion Criteria

•Other physical or psychiatric disorders
•Current substance abuse
•Current psychotherapy or other specific intervention
•Exclusion criteria applicable to MRI

Outcomes

Primary Outcomes

Change from Baseline in Hamilton Depression Rating Scale (HDRS) score at the end of intervention (after 5th session)

Time Frame: Before start trial (baseline), after intervention (appr. 2 months)

Secondary Outcomes

Change from Baseline in Hospital Anxiety and Depression Scale (HADS) anxiety score at the end of intervention (after 5th session)(Baseline, end of intervention (appr. 2 months))
Change from Baseline in Hamilton Depression Rating Scale (HDRS) score at follow-up(Baseline, 3-month follow-up)
Change from Baseline in Hospital Anxiety and Depression Scale (HADS) anxiety score at follow-up(Baseline, 3-month follow-up)
Change from Baseline in Hospital Anxiety and Depression Scale (HADS) depression score at the end of intervention (after 5th session)(Baseline, end of intervention (appr. 2 months))
Change from Baseline in the Quality of Life Scale (QOLS) at the end of intervention (after 5th session)(Baseline, end of intervention (appr. 2 months))
Change from Baseline in Hospital Anxiety and Depression Scale (HADS) depression score at follow-up(Baseline, 3-month follow-up)
Change from Baseline in the Quality of Life Scale (QOLS) at follow-up(Baseline, 3-month follow-up)
Change from Baseline in the European Quality of Life-5 dimensions scale (EQ-5D) at follow-up(Baseline, 3-month follow-up)
Change from Baseline in the European Quality of Life-5 dimensions scale (EQ-5D) at the end of intervention (after 5th session)(Baseline, end of intervention (appr. 2 months))