Incidence and prognostic impact of genomic alteration in endometrial cancer
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- To determine the incidence of various genomic mutations ( POLE, MSI and TP53 status )in EC by genetic analysis.
研究概览
简要总结
The project titled Incidence and Prognostic Impact of Genomic Alteration in Endometrial Cancer aims to determine the incidence of genetic mutations (POLE, MSI, and TP53) in endometrial carcinoma (EC) and analyze their correlation with clinical outcomes. This study will focus on patients diagnosed with EC at the Medical Oncology and Surgical Oncology OPD of IMS and SUM Hospital. The research will explore how these genomic alterations impact prognosis. Statistical analysis using SPSS and Kaplan-Meier methods will help assess survival outcomes and mutational patterns, contributing to improved treatment strategies.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- Female
入选标准
- •All cases of endometrial carcinoma attending medical oncology and surgical oncology OPD irrespective of stage.
排除标准
- •Patients who refuse to take part in this study.
- •Patients with other confounding factors such as prior radiation to pelvis, concomitant malignancy, HCV/HBsAg/HIV reactive, active TB, previously treated different malignancy.
结局指标
主要结局
To determine the incidence of various genomic mutations ( POLE, MSI and TP53 status )in EC by genetic analysis.
时间窗: 3 monthly and 6 monthly
次要结局
- To analyze the clinical outcomes and correlate them with various mutations according to histological variants of EC.(To analyze the outcome of POLE mutation, MSI, and TP53 in patients of EC.)
研究者
Dr Inimerla Bhavya
Institute of Medical sciences and SUM Hospital