Acid-Base Balance, Metabolism and Minerals
- Conditions
- Metabolic AcidosisAcid-Base Balance Disorder
- Registration Number
- NCT04229069
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes.
Within a randomized double-blind placebo-controlled trial, the investigators tested the hypotheses 1) that a 4-week protein-rich diet induces a latent tissue acidosis and 2) an alkaline supplement can compensate this. Acid-base balance and important metabolic parameters were determined before and after 4 weeks of supplementation by peripheral blood samples, indirect calorimetry and muscle microdialysis before and after a protein-rich test meal.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- slightly reduced kidney function (GFR 60-89 ml/min)
- Body mass index 20.0 - 29.9 kg/m2
- normal daily diet composition: 45-50, 35-40, and 15 E% from carbs, fats and proteins, respectively
- sorbitol-/fructose-intolerance
- intake of antacidic drugs
- vegetarians, vegans
- intake of any nutritional supplements
- any cardiovascular, pulmonary, endocrine or metabolic diseases
- any drug abuse
- intake of any anticoagulant drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in muscle dialysate lactate-pyruvate ratio before and after 4-weeks of supplementation at baseline (after a 12 hours overnight fast) and 60, 120, and 180 minutes after a protein-enriched test meal surrogate measure for muscle tissue pH
- Secondary Outcome Measures
Name Time Method