CHildhood ASthma and Environment Research Study - CHASER Study

• Conditions: Asthma

• Registration Number: NCT02433275
• Lead Sponsor: Stefania La Grutta, MD

Brief Summary

"CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology \& Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy.

The first phase - transversal study will identify determinants of pediatric asthma control

The second phase - longitudinal study, in patients with persistent asthma, will be focused on:

* predictors for asthma exacerbations and loss of control

* real life adherence to asthma therapy guidelines

* phenotypic characterization through the collection of saliva samples

* assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing

* evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis.

Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2015-04-29
• Study First Submitted QC: 2015-04-29
• Study First Posted: 2015-05-04
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-02
• Last Update Posted: 2022-08-03
• Primary Completion: 2022-12
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1600

Inclusion Criteria

• age 5-16 years
• asthma
• not asthma

Exclusion Criteria

• chest deformity
• active smoking

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Asthma	5 years

Secondary Outcome Measures

Name	Time	Method
Measures from saliva samples	5 years
Measures from nasal brushing	5 years
Measures from urine samples	5 years

Trial Locations

Locations (1)

Institute of Biomedicine and Molecular Immunology, IBIM; 🇮🇹 Palermo, Italy