Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Heart Failure
- Conditions
- Congestive Heart Failure
- Registration Number
- NCT00595738
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
The relationship between peripheral venous saturation and central hemodynamics (including right and left heart filling pressures and cardiac output), mixed venous oxygen saturation, and contemporary biomarkers of heart failure is not clear. We aim to determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure. We will determine the relationship between cardiac output measured via thermodilution and the Fick equation calculated using concurrent oxygen saturations from the distal PA, central vein, and peripheral vein. We also aim to examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure. Day 0-5 of 'tailored' heart failure therapy
- Secondary Outcome Measures
Name Time Method To examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure. Days 0-5 of 'tailored' heart failure therapy
Trial Locations
- Locations (1)
Massachusetts General Hospital, Coronary Care Unit
🇺🇸Boston, Massachusetts, United States
Massachusetts General Hospital, Coronary Care Unit🇺🇸Boston, Massachusetts, United States