Prehabilitation prior to oncological resection for stage I-III pancreatic ductal andenocarcinoma, esophageal and gastric cancer – a prospective feasibility study

• Conditions: C25; Malignant neoplasm of pancreas; C16; C15; Malignant neoplasm of stomach; Malignant neoplasm of oesophagus

• Registration Number: DRKS00034212
• Lead Sponsor: niversitätsklinikum Schleswig-Holstein, Campus Lübeck

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

Clinical UICC (Union internationale contre le cancer) stage I-III at time of diagnosis (Pancreatic cancer, esophageal cancer, gastric cancer)
- Scheduled for curative-intent therapy
- Age > 18 years and capable of signing informed consent

Exclusion Criteria

- Clinical UICC stage IV

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severe postoperative complications (Clavien Dindo classification grade IIIA-IVB), evaluation until 90 days after surgery

Secondary Outcome Measures

Name	Time	Method
Completion of prescribed curative-intent therapy (surgery and perioperative therapy), periop blood transfusion, length of hospital stay, physical fitness, toxicity events of perioperative therapy, dose reduction of perioperative therapy, quality of life, sarcopenia, chachexia, nutritional status, exocrine insufficiency, transfusion requirement, disease-free survival, overall survival, adherence to and feasibility of prehabilitation program for patients and caregivers