Efficacy of Intravenous Dexketoprofen and Tenoxicam on Propofol Associated Injection Pain

Phase 4

Completed

• Conditions: Injection Pain
• Interventions: Drug: saline; Drug: dexketoprofen; Drug: tenoxicam

• Registration Number: NCT02285972
• Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Brief Summary

Propofol remains the most common drug for induction of general anaesthesia, although it causes considerable pain or discomfort on injection. Anesthesia providers have attempted a large number of remedies to prevent this pain on injection. Previously explored ideas include injecting propofol into larger veins, warming of the hand with hot packs, and intravenous pretreatment with numerous other medications. No studies to date have looked at the dexketoprofen and tenoxicam for the pretreatment of pain on injection caused by propofol. The investigators propose studying the use of dexketoprofen and tenoxicam for pretreatment of propofol related pain on injection.

Detailed Description

Not available

Study Timeline

• Status Verified: 2014-11
• Study Start: 2014-11
• Study First Submitted: 2014-11-01
• Study First Submitted QC: 2014-11-04
• Study First Posted: 2014-11-07
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Last Update Submitted: 2015-04-18
• Last Update Posted: 2015-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status 1 and 2
• 18 - 65 years
• general anesthesia scheduled for elective surgery

Exclusion Criteria

• age < 18 years, > 65 years
• pregnancy
• patients requiring a rapid sequence induction
• refusal to participate and patients already participating in another study
• allergy to study drugs
• communication difficulty
• psychiatric and neurolojic disorders
• use of analgesics or sedative drugs within 24 hours before surgery.
• emergency surgery
• history of drug or alcohol abuse
• ASA 3 and above

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
saline	saline	-
dexketoprofen	dexketoprofen	-
tenoxicam	tenoxicam	-

Primary Outcome Measures

Name	Time	Method
Verbal Pain Score	Approximately one minute following administration of propofol.
Facial Pain Score	Approximately one minute following administration of propofol.

Trial Locations

Locations (1)

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital; 🇹🇷 Altınordu, Ordu, Turkey