Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt

Not Applicable

• Conditions: Decay, Dental
• Interventions: Other: saline; Other: chlorhexidine; Other: Propolis extract; Other: pomegranate extract

• Registration Number: NCT03623048
• Lead Sponsor: Cairo University

Brief Summary

Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Detailed Description

This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.

Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.

Study Timeline

• Study First Submitted: 2018-08-07
• Study First Submitted QC: 2018-08-08
• Study First Posted: 2018-08-09
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-08
• Last Update Posted: 2018-09-11
• Study Start: 2019-03
• Primary Completion: 2019-04
• Study Completion: 2019-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• High caries risk patients defined according to American Dental Association (ADA)
• Systematically healthy
• Not taking any medication interfering with saliva secretion
• Subjects who signed informed consent
• Age range from 17-50 years

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Exclusion Criteria

• Subjects suffering from any medical or systematic disease
• Smokers
• Pregnant females
• Allergy to any of the mouthwash ingredients
• Patients older than 50 years

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline	saline	comparator
Chlorhexidine	chlorhexidine	comparator
Propolis extract	Propolis extract	intervention
Pomegranate extract	pomegranate extract	intervention

Primary Outcome Measures

Name	Time	Method
Taste alteration	One week	taste changes will be measured by a questionnaire

Secondary Outcome Measures

Name	Time	Method
Salivary pH	one week	salivary pH will be measured by digital pH meter