Effect of Propolis and Pomegranate Extract Mouthwash on Taste Alteration, Salivary pH and Antibacterial Activity in High Caries Risk Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 主要终点
- Taste alteration
研究概览
简要总结
Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.
详细描述
This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.
Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 17 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •High caries risk patients defined according to American Dental Association (ADA)
- •Systematically healthy
- •Not taking any medication interfering with saliva secretion
- •Subjects who signed informed consent
- •Age range from 17-50 years
排除标准
- •Subjects suffering from any medical or systematic disease
- •Pregnant females
- •Allergy to any of the mouthwash ingredients
- •Patients older than 50 years
研究组 & 干预措施
Chlorhexidine
comparator
干预措施: chlorhexidine (Other)
Saline
comparator
干预措施: saline (Other)
Propolis extract
intervention
干预措施: Propolis extract (Other)
Pomegranate extract
intervention
干预措施: pomegranate extract (Other)
结局指标
主要结局
Taste alteration
时间窗: One week
taste changes will be measured by a questionnaire
次要结局
- Salivary pH(one week)
研究者
Randa Abdelrahman
Assistant lecturer
Cairo University