Real-time fMRI Neurofeedback for Treatment of Parkinson's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- Cardiff University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS)
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of the study is to train patients with Parkinson's Disease to increase activity in a brain area that is involved in the control of motor functions with the use of a technique called real-time fMRI neurofeedback (NF) along with regular physical exercise. This will be a randomised and controlled clinical trial to evaluate the benefits of a novel treatment. The investigators expect NF training along with physical exercise practise to better improve motor functions compared to physical exercise alone.
Investigators
David Linden
Professor of Translational Neuroscience
Cardiff University
Eligibility Criteria
Inclusion Criteria
- •People with Parkinson's Disease
- •Hoehn and Yahr stages 1-3 of the disease
Exclusion Criteria
- •Patients with dementia or significant comorbidity
- •those who fail the safety screening to go into an MRI scanner
- •those who cannot travel to the University
Outcomes
Primary Outcomes
Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS)
Time Frame: Change from Baseline in the 'Movement Disorder Society - Unified Parkinson's Disease Rating Scale' (MDS-UPDRS) in 12 weeks
Secondary Outcomes
- Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39)(Change from baseline in the 'Parkinson's Disease Questionnaire 39' (PDQ-39) in 12 weeks)
- Change from baseline in the 'Actigraph'(Change from baseline in the 'Actigraph' at 12 weeks)
- Change from baseline in the 'GaitRite'(Change from baseline in the 'GaitRite' at 12 weeks)