To compare the effect of use of both intravenous and intra articular injection of tranexamic acid with only intra-articular injection of tranexamic acid in reducing blood loss in total knee replacement patients in western india
Phase 1
Completed
- Conditions
- Health Condition 1: null- All patients who are undergoing primary TKAHealth Condition 2: M179- Osteoarthritis of knee, unspecified
- Registration Number
- CTRI/2018/05/014106
- Lead Sponsor
- Yeshi Dorji
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 31
Inclusion Criteria
In combined Group-1gm of TXA using I.V injection 15 mins before skin incision and 1gm of TXA using intra-articular intra operatively after closure of joint capsule in primary TKA
Single group-Receives only 1gm of TXA intra-articular intraoperatively after joint capsule closure in primary TKA.
Exclusion Criteria
Patient unwilling for study-no consent
Patients allergic to TXA
Patient with known history of thromboembolic disease
Patients with cardiovascular disease like MI
Patients with history of cerebral vascular disease- stroke
pre op renal dysfunction
pre op coagulopathy plt less than 1.5lakh and INR more than 1.4
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compare Fall in Haemoglobin level,haematocrit and Drain outputTimepoint: post operative day Hb level on day 3, day 5 and day 14 <br/ ><br>Drain output is measured after 24 hours post surgery
- Secondary Outcome Measures
Name Time Method To evaluate the amount of blood loss with combined (intravenous and intra-articular) TXA in primary TKA <br/ ><br>To evaluate amount of blood loss with only intra-articular administration of TXA in primary TKATimepoint: Post operative day1,3,5 & 14