Effects of Low-Flow Anesthesia on Hemodynamic Parameters and Oxygenation in Morbidly Obese Patients
- Conditions
- Bariatric Surgery CandidateMorbid ObesityHemodynamic Instability
- Interventions
- Diagnostic Test: hemodynamic parametersDiagnostic Test: arterial blood gase
- Registration Number
- NCT03721536
- Lead Sponsor
- Inonu University
- Brief Summary
Low-flow anesthesia has been used for years with positive results, but its effects on hemodynamic parameters and oxygenation are not clearly known in high-risk morbidly obese patients who are prone to pulmonary dysfunction related to the obesity. Therefore, this prospective randomized study aimed to compare the effects of low-flow (0.75 L/min) and normal-flow (1.5 L/min) anesthesia on hemodynamic parameters and oxygenation in morbidly obese patients undergoing laparoscopic bariatric surgery.
- Detailed Description
Low-flow anesthesia has several potential benefits. It improves the flow dynamics of the inhaled air, increase mucociliary clearance, maintain body temperature, reduce fluid loss, result in savings of up to 75% and reduce greenhouse gas emissions and reduce treatment costs (10 - 13). However, it is necessary to examine whether the reduction of fresh gas flow affects the quality and safety of anesthesia management, especially during high-risk operations such as laparoscopic bariatric surgery.
Low-flow anesthesia has been used for years with positive results, but its effects on hemodynamic parameters and oxygenation are not clearly known in high-risk morbidly obese patients who are prone to pulmonary dysfunction related to the obesity. Therefore, this prospective randomized study aimed to compare the effects of low-flow (0.75 L/min) and normal-flow (1.5 L/min) anesthesia on hemodynamic parameters and oxygenation in morbidly obese patients undergoing laparoscopic bariatric surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
- Morbidly obese patients with American Society of Anesthesiology (ASA) scores of III-IV,
- Aged 18-65 years old,
- BMI>40
- Pregnant
- Uncontrolled diabetes mellitus,
- Cardiovascular disease,
- Pulmonary disease,
- Cerebrovascular disease,
- Drug and alcohol addiction.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description low-flow anesthesia hemodynamic parameters Patients in low-flow anesthesia receive a fresh gas flow of 4 L/min for the first 10 minutes and were then maintain with a fresh gas flow of 0.75 L/min. Patients will be monitored for hemodynamic parameters during the perioperative period. Arterial blood gase will be analyzed for the oxygenation. low-flow anesthesia arterial blood gase Patients in low-flow anesthesia receive a fresh gas flow of 4 L/min for the first 10 minutes and were then maintain with a fresh gas flow of 0.75 L/min. Patients will be monitored for hemodynamic parameters during the perioperative period. Arterial blood gase will be analyzed for the oxygenation. normal-flow anesthesia arterial blood gase Patients in normal-flow anesthesia received a fresh gas flow of 4 L/min for the first 10 minutes and were then maintained with a fresh gas flow of 1.5 L/min. Patients will be monitored for hemodynamic parameters during the perioperative period. Arterial blood gase will be analyzed for the oxygenation. normal-flow anesthesia hemodynamic parameters Patients in normal-flow anesthesia received a fresh gas flow of 4 L/min for the first 10 minutes and were then maintained with a fresh gas flow of 1.5 L/min. Patients will be monitored for hemodynamic parameters during the perioperative period. Arterial blood gase will be analyzed for the oxygenation.
- Primary Outcome Measures
Name Time Method The level of partial oxygen pressure From beginning of Anesthesia induction to the end of anesthesia (during perioperative period) The level of partial oxygen pressure is measured as mmHg in arterial blood gase analysis
- Secondary Outcome Measures
Name Time Method Heart rate From beginning of Anesthesia induction to the end of anesthesia (during perioperative period) Heart rate is measured as beats/minute on the anesthesia monitor
Mean arterial pressure From beginning of Anesthesia induction to the end of anesthesia (during perioperative period) Mean arterial pressure is measured as mmHg on the anesthesia monitor
Peripheral oxygen saturation From beginning of Anesthesia induction to the end of anesthesia (during perioperative period) Peripheral oxygen saturation is measured as percentage (%) on the anesthesia monitor
Trial Locations
- Locations (1)
Sedat Akbas
🇹🇷Malatya, Türkiye-Türkçe, Turkey