Evaluation of Viral Diagnostics on rEspiratory iNfections in ChildrE

Completed

Conditions: Acute respiratory infections
Respiratory
Acute upper respiratory infections

Registration Number: ISRCTN13015410

Lead Sponsor: Reinier de Graaf Hospital (Netherlands)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 600

Inclusion Criteria

1. Children under age of 2 months with a respiratory tract infection
2. Children older than 2 months with a respiratory tract infection and severe respiratory problems with tachypnoea, dyspnoea or cyanosis
3. Gender: both male and female

Exclusion Criteria

Aged older than 12 years

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in clinical decision making: <br>1. Hospital admission yes or no: measured at first clinical presentation<br>2. Duration of hospital stay in days: measured after discharge at hospital<br>3. Start of antibiotics yes or no: measured at any time from first presentation until discharge<br>4. Duration of antibiotic use in days when initiated: measured after discharge

Secondary Outcome Measures

Name	Time	Method
Epidemiology of respiratory tract infections in children; all measured at any time from first presentation until discharge:<br>1. Clinical symptoms and disease severity of new viral pathogens; are there differences between the pathogens?<br>2. Clinical symptoms and disease severity of multiple infections; differences with monoinfections<br>3. Relation between viruses and laboratory parameters (C-reactive protein [CRP] for example)<br>4. What is the role of Bordetella pertussis in children with acute respiratory infection and should it be tested routinely<br>5. Cost changes as a result of introduction of PCR diagnostics