Impact of Different Treatment Strategies on the Prognosis of Ovarian Metastatic Colorectal Cancer Patients: a Prospective, Multi-center, Real-world Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ovarian Metastasis
- Sponsor
- West China Hospital
- Enrollment
- 400
- Locations
- 4
- Primary Endpoint
- Ovarian specific overall survival
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This prospective, multi-center, real-world study is conducted to investigate the impact of different treatment strategies (systemic chemotherapy combined with oophorectomy or with other local treatment or chemotherapy alone) on the prognosis of ovarian metastatic colorectal cancer patients.
Detailed Description
This study prospectively collects data of patients diagnosed with ovarian metastatic colorectal cancer, meeting inclusion criteria and signing the informed consent. Patients' treatment strategies and survival outcome in the real world will be faithfully recorded.
Investigators
Meng Qiu
Prof.
West China Hospital
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed colorectal adenocarcinoma;
- •Histologically or radiologically diagnosed with ovarian metastasis, whether or not combined with metastases in other organs;
- •Women ≥18 years of age;
- •Eastern Cooperative Oncology Group performance status score ≤2;
- •Available imaging data if the disease is measurable according to RECIST criteria version 1.1; patients are eligible if there is no measurable lesion.
- •Complete medical records;
- •Informed consent form signed.
Exclusion Criteria
- •Not ovarian metastatic colorectal cancer confirmed by radiology or histology;
- •Drug abuse or other medical, psychological and social disorders that would interfere with cooperation with the requirements of the study;
- •Other conditions that would influence patient compliance;
- •Pregnant or breastfeeding female; male and female unwilling to take any contraceptive measures.
Outcomes
Primary Outcomes
Ovarian specific overall survival
Time Frame: up to 3 years
Calculated from the date of diagnosis with ovarian metastasis to death (caused by cancer) or last follow-up time.
Secondary Outcomes
- Ovarian specific objective response rate(6 months)
- Quality of life questionnaire(6 months)
- Extra-ovarian specific objective response rate(6 months)
- Progression free survival(6 months)