Clinical study of Zhenzhu Qingyuan granule in the treatment of gastroesophageal reflux disease of liver-stomach heat retention type
- Conditions
- Gastrointestinal reflex disease
- Registration Number
- ITMCTR2000003674
- Lead Sponsor
- Xiyuan Hospital CACMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. The age ranged from 18 to 65 years old.
2. The patients who meet the GERD diagnostic criteria were divided into three types: NERD, RE and BE according to the results of gastroscopy.
3. Results of gastroscopy in Grade-A Tertiary Hospital within 2 weeks of approval.
4. All the patients were in accordance with the diagnosis of liver-stomach heat retention type.
5. Those who have not taken traditional Chinese medicine for the treatment of GERD for at least 3 months.
6. Volunteer to participate in this experiment and sign informed consent.
1. Patients with severe peptic ulcer, history of digestive tract surgery, gastrointestinal malignant disease and other serious complications.
2. Pregnant or lactating women.
3. Patients with severe liver and kidney dysfunction, malignant tumors, and cardiovascular and cerebrovascular diseases assessed by anesthesiologists who cannot tolerate general anesthesia.
4. Patients with other diseases such as immunity and organ failure.
5. Combined with mental patients who are unable to control the possibility of injuring others.
6. Patients with other serious infectious diseases, such as pulmonary tuberculosis and positive anti-HIV.
7. Those who have participated in other clinical trials in recent 3 months.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TCM symptom score;
- Secondary Outcome Measures
Name Time Method RDQ;Reflux symptom score;Gerd Q;Inflammation score under endoscopy;