Practical Approach for Identifying Malnutrition and Its Relation to Outcome in Critically Ill Children: A Prospective Cohort Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Assiut University
- Enrollment
- 103
- Primary Endpoint
- Nutritional status at PICU admission assessed by ABCD approach
Study Overview
Brief Summary
This prospective cohort study aims to assess the nutritional status of critically ill children aged 1 month to 5 years admitted to the pediatric intensive care unit using a comprehensive ABCD approach including anthropometric, biochemical, clinical, and dietary assessment within 48 hours of admission, and to evaluate its association with clinical outcomes including duration of mechanical ventilation, length of PICU stay, and mortality.
Detailed Description
Malnutrition is common among critically ill children in PICU with prevalence around 37 percent. This study will include children admitted to PICU at Assiut University Children Hospital with expected stay greater than 48 hours. Nutritional status will be assessed within 48 hours using anthropometric measurements weight height body mass index mid-upper arm circumference skinfold thickness, biochemical markers albumin prealbumin total protein C-reactive protein electrolytes, clinical examination for muscle and fat loss, and dietary intake. Children will be followed up to 30 days for clinical outcomes.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 1 Month to 5 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age from 1 month to 5 years
- •Admitted to PICU with expected length of stay greater than 48 hours
- •Written informed consent from parents or legal guardians
Exclusion Criteria
- •Chronic renal or hepatic disease known to affect serum protein levels
- •Incomplete medical records or discharged or transferred before first laboratory sample could be obtained
- •Receiving nutritional support enteral or parenteral prior to PICU admission for condition unrelated to current critical illness
Arms & Interventions
Critically ill children in PICU
Children aged 1 month to 5 years admitted to PICU with expected stay greater than 48 hours who will undergo comprehensive nutritional assessment using ABCD approach within 48 hours of admission
Outcomes
Primary Outcomes
Nutritional status at PICU admission assessed by ABCD approach
Time Frame: At baseline within 48 hours of admission
Number of children classified as malnourished based on comprehensive ABCD assessment including anthropometric measurements body mass index z-score mid-upper arm circumference skinfold thickness, biochemical markers albumin prealbumin total protein, clinical signs of muscle and fat loss, and dietary intake, obtained within 48 hours of PICU admission
Secondary Outcomes
- Duration of mechanical ventilation(Up to 30 days)
- Length of PICU stay(Up to 30 days)
- PICU mortality(Up to 30 days)
- Feeding intolerance and refeeding syndrome(Up to 30 days)
Investigators
Merna Atef Felly
Resident Physician
Assiut University