Epidural use and cancer recurrence

Not Applicable

Completed

• Conditions: Cancer surgery; Anaesthesiology - Anaesthetics; Cancer - Biliary tree (gall bladder and bile duct)

• Registration Number: ACTRN12607000637448
• Lead Sponsor: Professor Paul Myles

Brief Summary

ong term follow-up data were available for 94% (n=446) of eligible participants. The median time to recurrence of cancer or death was 2.8 years in the control group and 2.6 years in the epidural group. Recurrence free survival was similar in both epidural and control groups .

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-12-13
• Study Completion: 2010-08-02
• Last Update Posted: 21 September 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 503

Inclusion Criteria

Patients previously enrolled in MASTER Trial 1995-2001. ASA III-IV patients (American Society of Anesthesiology physical status classification) having major abdominal surgery.

Exclusion Criteria

Patients not enrolled in MASTER Trial. Patients were excluded if they were inelligible for epidural anaesthesia due to sepsis, impaired coagulation status, infection at epidural puncture site, non-vascular disorder or impaired mental state.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recurrence-free survival[7-13 years postoperatively]

Secondary Outcome Measures

Name	Time	Method
All cause mortality[7-13 years postoperatively]