A Clinical Study to Evaluate the Efficacy of Pashanabhedadi Churnam with and without Yavakshara in the management of Mutrashmari w.s.r Urolithiasis
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To Reduce the Signs and Symptoms of Renal Calculi and break the stones
研究概览
简要总结
Mutrashmari, one of the Ashta Mahagadas (eight grave disorders) in Ayurveda, is a disease of the Mutravaha Srotas (urinary system) characterized by the formation of stone-like structures (ashmari) within the urinary tract. It closely correlates with the modern medical condition urolithiasis, which refers to the formation of calculi in the kidneys, ureters, bladder, or urethra.
The pathogenesis of Mutrashmari involves the vitiation of Tridoshas, especially Kapha dosha acting as a binding agent, along with obstruction and stagnation in the urinary channels. This results in crystallization of urinary constituents, leading to stone formation. Clinical features described in Ayurveda—such as painful urination (mutrakricchra), hematuria (raktamutrata), retention of urine (mutraghata), and radiating pain—align well with symptoms observed in modern urolithiasis.
Ayurvedic management includes herbal diuretics, litholytic drugs (Ashmarighna dravyas), Panchakarma procedures (like Basti), and lifestyle modifications, which aim at both dissolving stones and preventing recurrence.
This study aims to evaluate the clinical efficacy and safety of Ayurvedic interventions in the management of Mutrashmari (urolithiasis), establishing a validated integrative approach through traditional knowledge and modern diagnostic tools.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
入选标准
- •Patients with classical signs and symptoms of Mutrashmari will be included such as Mutrakrccha(Difficulty in micturition) Mutradaha (Burning micturition) Vedana sthapana(Pain) Sarakta mutrata(Hematuria) Visheerna dhara (Interrupted flow of urine) Patients with age group between 18 to 65yrs will be selected irrespective of Gender, Occupation and Socio economic status will be included.
- •Calculi measuring upto 10mm that located in kidney, ureter and urinary Bladder.
- •Patients who are willing to give consent for the clinical study.
排除标准
- •Age of below 18 and above 65years will be excluded.
- •Size is more than 10mm.
- •Patients with uncontrolled Diabetes and Hypertension.
- •Pregnant and Lactating women.
- •Sexually transmitted diseases, Malignancy and other Systemic disorders which interfers with the course of treatment will be excluded.
结局指标
主要结局
To Reduce the Signs and Symptoms of Renal Calculi and break the stones
时间窗: break the stones with in 3 months along with signs and symptoms
次要结局
- To Prevent Recurrence of Renal Calculi(90 days)
研究者
Dr K Asha Madhuri
Dr.BRKR Govt Ayurvedic College and Hospital