Characterization of Epicardial and Pericardial Adipose Tissue in Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Characterization of cardiac adipose tissue
研究概览
简要总结
Human epicardial fat is the true visceral fat depot of the heart, and its regional distribution and physiology is of growing scientific and clinical interest. This study aims to characterize the expression profile and function of the epicardial and pericardial adipose tissue compartments of the heart (EAT and PAT). EAT and PAT adipose biopsies will be obtained from patients undergoing coronary artery bypass graft surgery (CABG) or valve replacement surgery.
详细描述
The epicardial adipose tissue (EAT) stretches from the myocardium to the visceral layer of the pericardium. Adipose located on the outside of the visceral pericardium to the external site of the pericardium is called the pericardial adipose tissue (PAT), and is of a separate origin than EAT. Therefore, this study aims to investigate the global expression profile of the EAT and PAT compartments, in addition to characterizing the function, structure, metabolic and inflammatory profile. Furthermore, this study will determine whether CABG and valve replacement patients display different EAT and PAT characteristics
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age <80 years
- •Patients undergoing elective heart surgery either for coronary bypass grafting or for other purposes
排除标准
- •Inability of the patient to provide informed consent
- •Severe kidney failure, GFR<30
- •Previous cardio-thoracic surgery
- •There are no other specific exclusion criteria, as long as the patient is considered eligible for surgery by the clinicians
结局指标
主要结局
Characterization of cardiac adipose tissue
时间窗: Time of collection during surgery is approximately 3 hours
Cardiac adipose tissue biopsies will be compared and characterized as brown, beige or white adipose according to gene expression of adipocyte markers
次要结局
- Characterization of cardiac adipose tissue gene expression in coronary artery bypass graft (CABG) and valve replacement surgery patients(Time of collection during surgery is approximately 3 hours)
- Characterization of cardiac adipose tissue protein expression in coronary artery bypass graft (CABG) and valve replacement surgery patients(Time of collection during surgery is approximately 3 hours)
- Functional characterization of cardiac adipose biopsy cell culture(Time of collection during surgery is approximately 3 hours)
- Cardiac adipose tissue volume(Prior to surgery)
- Cardiac muscle biopsies(Time of collection during surgery is approximately 3 hours)
研究者
Regitse Christensen
MD
Rigshospitalet, Denmark