The effect of esomeprazole on acid suppression in Japanese-evaluation with the endoscopic gastrin test, EGT
Not Applicable
- Conditions
- Gastroesophageal reflux disease
- Registration Number
- JPRN-UMIN000009065
- Lead Sponsor
- Division of Gastroenterology, Tohoku University Graduate Schooi of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
Not provided
Exclusion Criteria
1. Subjects with past history of drug allergy 2. Subjects with hepatic, renal, or cardiac disorder 3. Subjects with a history of gastrectomy and/or vagotomy 4. Subjects who are on any treatment 5. Subjects who need to receive any drugs other thanthe study drug during the study. 6. Others as judged inappropriate by the investigator(s)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the rate of acid suppression at the steady state(at 14:00 on day7) among each group.
- Secondary Outcome Measures
Name Time Method To compare the rate of acid suppression of esomeprazole at 8:00 on day15* among each group. *at 8:00 on day15: Twenty-four hours after last administration for once daily and 10 hours after last administration for twice daily To evaluate the background factors that affect the acid suppression, such as H.pylori infecton, CYP2C19 polymophism in three groups.