Effect of Hydroxychloroquine in patients with repeated implantation failure

Phase 3

Recruiting

• Conditions: Repeated Implantation Failure.; Female infertility of uterine origin; N-97.2

• Registration Number: IRCT2017060634209N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

Patients having an immunological disorder in serum (Tumor necrosis factor alpha/Interleukin-10>= 30.6); 3 failed embryo transfer
Exclusion criteria: uterine abnormality (acquired or congenital); unwillingness to continue

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin -10. Timepoint: Twice: before and after intervention. Method of measurement: Immunohistochemistry.;Tumor necrosis factor alfa. Timepoint: Twice: before and after intervention. Method of measurement: Immunohistochemistry.;Interleukin-17. Timepoint: Twice: before and after intervention. Method of measurement: Immunohistochemistry.;GATA3 gene. Timepoint: Twice: before and after intervention. Method of measurement: Polymerase chain reaction.;Interleukin-4. Timepoint: Twice: before and after intervention. Method of measurement: Immunohistochemistry.;T-bet gene. Timepoint: Twice: before and after intervention. Method of measurement: Polymerase chain reaction.;FOXP-3 gene. Timepoint: Twice: before and after intervention. Method of measurement: Polymerase chain reaction.;ROR?t gene. Timepoint: Twice: before and after intervention. Method of measurement: Polymerase chain reaction.

Secondary Outcome Measures

Name	Time	Method
Chemical pregnancy. Timepoint: 2 weeks after embryo transfer in next cycle. Method of measurement: Serum BHCG.