Treatment of Hypertension
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Cardiovascular Diseases
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.
Detailed Description
BACKGROUND: This grant-supported, cooperative, fixed-protocol clinical study was initiated in 1966 and followed a cooperative study of the treatment of renal hypertension initiated in 1960 to evaluate the relative efficacy of several recognized drug regimens for reduction of blood pressure. Six centers (USPHS hospitals) and a coordinating center were involved in the trial. DESIGN NARRATIVE: Randomized, double-blind, fixed sample. Three hundred and eighty nine eligible patients were assigned to drug therapy consisting of chlorothiazide plus Rauwolfia serpentina or to placebo. The study completion date listed in this record was inferred from last publication listed in the Citations section of this study record.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Not specified