Choosing the right antidepressant for people with unipolar depressio

Not Applicable

• Conditions: nipolar depression; Mental and Behavioural Disorders

• Registration Number: ISRCTN82850103
• Lead Sponsor: niversity of Oxford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-11-07
• Last Update Posted: 21 November 2022
• Study Completion: 2023-09-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 504

Inclusion Criteria

1. Participant is willing and able to give informed consent for participation in the trial
2. Aged 18 -74 years
3. Clinical diagnosis of depressive disorder and for whom an antidepressant is clinically indicated
4. Participants willing to take antidepressant treatment, but have not been treated with antidepressants in the previous 4 weeks
5. Willing to meet any clinical requirements related to taking a specific medication
6. Able to read/understand and/or complete self-administered questionnaires online in English

Exclusion Criteria

1. Prescribed any antidepressant in the preceding 4 weeks
2. Current or historical diagnosis of ADHD, alcohol/substance use disorder, bipolar disorder, dementia, eating disorders, mania/hypomania, OCD, PTSD, psychosis/schizophrenia, treatment-resistant depression (having tried two or more antidepressants for the same depressive episode at adequate dose and time)
3. Diagnosis of arrhythmias (including Q-T prolongation, heart block), recent MI, poorly controlled epilepsy, acute porphyrias
4. Require urgent mental care or admission (including suicidal intent/plans)
5. Concurrently enrolled in another investigational medicinal product (IMP) trial or an interventional trial about depression
6. Participants who are currently pregnant, planning pregnancy or lactating
7. Has a medical, social or other condition which, in the investigator’s opinion, may make the participant unable to comply with all the trial requirements (e.g., terminal illness – motor neuron disease)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of participants who are still taking the allocated antidepressants after 8 weeks, collected by trained clinicians during the study visits and documented in the trial’s case report forms