Online therapy programme for fatigue in multiple sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis (MS); Nervous System Diseases; Multiple sclerosis

• Registration Number: ISRCTN25692173
• Lead Sponsor: Hertie Foundation (Germany) (Gemeinnützige Hertie Stiftung)

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29549193

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-06-06
• Study Completion: 2015-05-26
• Last Update Posted: 30 April 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 204

Inclusion Criteria

1. Definite MS according to McDonald criteria (Polman et al., 2010), relapsing-remitting (RR), primary and secondary-progressive (SP) MS course
2. Ability to answer read texts and to answer questionnaires via the internet
3. Fatigue-Scale-Motor-Cognition (FSMC) total fatigue score >= 43
4. Internet equipment at home (PC with internet access)
5. Interest to attend (agreement)

Exclusion Criteria

1. Unclear diagnosis
2. Neuromyelitis optica
3. Major psychiatric disease (f.e. psychotic disease, but we will allow depressive disorders)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fatigue as measured by the Chalder Fatigue Scale (Cella & Chalder et al., 2010). Pre-post training comparisons immediately after the training and 3 months later will be calculated.

Secondary Outcome Measures

Name	Time	Method
1. Fatigue: FSMC (Penner et al., 2009)<br>2. Anxiety and depression: Hospital Anxiety and Depression Scale (HADS, Zigmond & Snaith, 1983)<br>3. Quality of life: Hamburg Quality of Life Questionnaire in MS (HAQUAMS, Gold et al., 2001)<br>4. Cognitive self assessment: Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ, Benedict et al., 2003)<br>Exploratory:<br>5. Cognitive and behavioural responses to symptoms questionnaire (Skerett & Moss-Morris, 2006)<br>6. Brief Illness Perception Questionnaire (Broadbent et al., 2006)<br>7. Coping Self Efficacy Scale (CSES, Chesney et al., 2006)<br>8. Activity of daily life: Frenchay Activity Index (Turnbull et al., 2000)<br>9. Personality: Revised NEO Personality Inventory (Costa & McCrae,1992)