Effectiveness of Yoga on Composite Biomarker Age Predictorsin an Elderly Indian Cohort-A Two Armed open label Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Albumin, blood urea nitrogen, creatinine, C-reactive protein, cytomegalovirus
研究概览
简要总结
A wide spectrum of health benefits have been reported to be associated with yoga, that include improved cognition, respiration, reduced cardiovascular risk, body mass index, blood pressure, glycemic control (diabetes) and other levels of endocrine control. In elderly populations, Yoga-based interventions have been physiological effects in elderly. However, most of these interventions have targeted the mobility, flexibility, cognition, gait, fraility, self-rated health and well-being as the outcomes. The cumulative benefits indicate towards an ability of yoga in aiding physiological integrity. Hence we aim to test the effect of yoga on indicators of physiological multisystem decline well captured by the KDM-based BA estimates
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 60.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Willing to participate in the interventions
- •No presence of implanted devices or metallic bodies above the waist
- •No history of stroke or Transient ischemic attack (TIA)
- •Intention to remain in the local area for the duration of the intervention or testing period.
排除标准
- •Clinically advised not to perform exercises
- •Prior exposure to Yoga; involved in current or recent (last two months) practice of yoga or those with regular (three times per week or more) participation in other planned exercises, such as aerobics or strength training
- •Known accelerated hypertension
- •Overt clinical congestive heart failure requiring treatment with a diuretic or angiotensin converting enzyme inhibitor.
- •Renal failure (serum creatinine of more than 150 µmol/l)
- •Condition expected to severely limit survival, e.g. terminal illness
- •Resident in a nursing home, i.e. where the dependency and care requirements of the patients are such that they require the regular input of qualified nurses and therefore the majority of staff in the home are nurses (other forms of residential care are acceptable).
- •Unable to stand up or walk
- •Participation in a drug trial within the past month preceding selection.
- •Alcohol or drug abuse.
结局指标
主要结局
Albumin, blood urea nitrogen, creatinine, C-reactive protein, cytomegalovirus
时间窗: 3 time points | Baseline | 6th month | 12th month
KDM-based BA estimates
时间窗: 3 time points | Baseline | 6th month | 12th month
optical density, glycated hemoglobin, total cholesterol, white blood cell count, lymphocyte percent, mean corpuscular volume, and systolic blood pressure
时间窗: 3 time points | Baseline | 6th month | 12th month
次要结局
- IL-6,TNF alpha-receptor II, CRP, GDF15, insulin, IGF1, cystatin C, NT-proBNP, hemoglobin A1c.(Walk-speed test, grip-strength, forced expiratory volume test, Balance, Quality of life, Loneliness scale and cognition)