Single centric Non randomized open clinical trial Phase II in Madhumegam (Type II Diabetes mellitus) with Siddha Medicine Pavala silasathu parpam

Diabetes mellitus is a clinical syndrome characterised by increase in plasma blood glucose (Hyperglycemia). There are two types of diabetes mellitus ,Type I and Type II. Type I Diabetes Mellitus is caused by autoimmune destruction of beta cells in the pancreas, resulting in absolute insulin deficiency, whereas Type I Diabetes Mellitus is due to insulin deficiency or defective action of insulin or both. Chronic hyperglycemia is responsible for diabetes specific microvascular complications affecting the eyes (retinopathy), kidneys (nephropathy) and feet (neuropathy).

India is deemed as the world’s capital of Diabetes. In 2021, approximately 537 million adults (20-79years of age ) are living with diabetes. The total number of people living with diabetes is projected to rise to 643 million by 2030 and 783 million by 2045.The diabetic population in the country close to hitting the alarming mark of 69.9 million by2030.

The classical siddha medicine formulation “PAVALA SILASATHU PARPAM” mentioned in "Kannusamy Parambarai Vaithiyam". is indicated for Madhumegam (Type II Diabetes mellitus). Moreover this formulation has anti-diabetic activity that had been proven scientifically .So the author tries to evaluate its efficacy in the management of Type II Diabetes Mellitus in a non-randomised open clinical trial.