CIRculating CANcer MAster-Protocol

Recruiting

• Conditions: Adult With Solid Cancer
• Interventions: Biological: Blood sampling for biomarker analysis (microRNA, circulating DNA…)

• Registration Number: NCT05089747
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

This exploratory study will focus on the development of the analyses of blood biomarkers to better understand the circulating biomarkers associated with cancer diagnosis, treatment efficacy and progressive disease

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2021-10-11
• Study First Submitted QC: 2021-10-21
• Study First Posted: 2021-10-22
• Study Start: 2022-12-05
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-21
• Last Update Posted: 2023-07-24
• Primary Completion: 2047-12-01
• Study Completion: 2047-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 6000

Inclusion Criteria

• Adult (>18y)
• Owing a social security insurance
• Any solid cancer diagnosed by histopathology or cytology
• Patient with blood sampling required as per standard of care
• Informed consent signed

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Exclusion Criteria

• Refusal to participate
• No blood sampling required as per standard of care
• Hemoglobin < 7g/dl (< 9g/dl if respiratory or cardiovascular disease history)
• Heterologous blood transfusion in the last 48 hours
• Weight under 20 kg

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Adult with solid cancer. No intervention.	Blood sampling for biomarker analysis (microRNA, circulating DNA…)	-

Primary Outcome Measures

Name	Time	Method
Liquid biopsy analyses	Day 0	Extraction of circulating DNA or circulating RNA followed by a tumoral cells extraction.
Standard technics of disease assessment	Week 16	Genetic and transcriptomic explorations with immunofluorescence technique. Marking with specific markers of the tumor pathology. And enumaration of tumoral cells.
Correlation between outcome 1 and outcome 2	year 5	Building a biological collection of blood samples and following, diagnosis and prediction of adult solid cancer.

Trial Locations

Locations (5)

Oncologie médicale Hôpital Lyon-Sud / Groupement Hospitalier Sud; 🇫🇷 Pierre-Bénite, France

Service de Pneumologie Hôpital Louis Pradel / Groupement Hospitalier Est; 🇫🇷 Bron, France

Service de Pneumologie Aigue Spécialisée et Cancérologie Thoracique Hôpital Lyon-Sud / Groupement Hospitalier Sud; 🇫🇷 Pierre-Bénite, France

Service de dermatologie Hôpital Lyon-Sud / Groupement Hospitalier Sud; 🇫🇷 Pierre-Bénite, France

Service de Pneumologie Hôpital Croix-Rousse / Groupement Hospitalier Nord; 🇫🇷 Lyon, France