MAster Protocol Studying the Impact of Blood Biopsy on Screening, Diagnosis, Diagnostic and Follow-up of Solid Cancer in Adult

Hospices Civils de Lyon5 sites in 1 country6,000 target enrollmentDecember 5, 2022

ConditionsAdult With Solid Cancer

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Adult With Solid Cancer
Sponsor: Hospices Civils de Lyon
Enrollment: 6000
Locations: 5
Primary Endpoint: Liquid biopsy analyses
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This exploratory study will focus on the development of the analyses of blood biomarkers to better understand the circulating biomarkers associated with cancer diagnosis, treatment efficacy and progressive disease

Registry

clinicaltrials.gov

Start Date

December 5, 2022

End Date

December 1, 2047

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Hospices Civils de Lyon

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Adult (\>18y)
•Owing a social security insurance
•Any solid cancer diagnosed by histopathology or cytology
•Patient with blood sampling required as per standard of care
•Informed consent signed

Exclusion Criteria

•Refusal to participate
•No blood sampling required as per standard of care
•Hemoglobin \< 7g/dl (\< 9g/dl if respiratory or cardiovascular disease history)
•Heterologous blood transfusion in the last 48 hours
•Weight under 20 kg

Outcomes

Primary Outcomes

Liquid biopsy analyses

Time Frame: Day 0

Extraction of circulating DNA or circulating RNA followed by a tumoral cells extraction.

Standard technics of disease assessment

Time Frame: Week 16

Genetic and transcriptomic explorations with immunofluorescence technique. Marking with specific markers of the tumor pathology. And enumaration of tumoral cells.

Correlation between outcome 1 and outcome 2

Time Frame: year 5

Building a biological collection of blood samples and following, diagnosis and prediction of adult solid cancer.